ApoE Genotype-Dependent Response to Antioxidant and Exercise Interventions on Brain Function

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dc.creatorChaudhari, Kiran
dc.creatorWong, Jessica M.
dc.creatorVann, Philip H.
dc.creatorComo, Tori
dc.creatorO'Bryant, Sid E.
dc.creatorSumien, Nathalie
dc.creator.orcid0000-0003-0582-5266 (O'Bryant, Sid E.)
dc.creator.orcid0000-0002-0077-9873 (Sumien, Nathalie)
dc.date.accessioned2022-07-07T13:54:25Z
dc.date.available2022-07-07T13:54:25Z
dc.date.issued2020-06-25
dc.description.abstractThis study determined whether antioxidant supplementation is a viable complement to exercise regimens in improving cognitive and motor performance in a mouse model of Alzheimer's disease risk. Starting at 12 months of age, separate groups of male and female mice expressing human Apolipoprotein E3 (GFAP-ApoE3) or E4 (GFAP-ApoE4) were fed either a control diet or a diet supplemented with vitamins E and C. The mice were further separated into a sedentary group or a group that followed a daily exercise regimen. After 8 weeks on the treatments, the mice were administered a battery of functional tests including tests to measure reflex and motor, cognitive, and affective function while remaining on their treatment. Subsequently, plasma inflammatory markers and catalase activity in brain regions were measured. Overall, the GFAP-ApoE4 mice exhibited poorer motor function and spatial learning and memory. The treatments improved balance, learning, and cognitive flexibility in the GFAP-ApoE3 mice and overall the GFAP-ApoE4 mice were not responsive. The addition of antioxidants to supplement a training regimen only provided further benefits to the active avoidance task, and there was no antagonistic interaction between the two interventions. These outcomes are indicative that there is a window of opportunity for treatment and that genotype plays an important role in response to interventions.
dc.description.sponsorshipThis research was funded by the Alzheimer's Association, grant number NIRG-10-173988, by the Pine Family Foundation (gift) and by UNT HSC Bridge Funding, grant number RI6096.
dc.identifier.citationChaudhari, K., Wong, J. M., Vann, P. H., Como, T., O'Bryant, S. E., & Sumien, N. (2020). ApoE Genotype-Dependent Response to Antioxidant and Exercise Interventions on Brain Function. Antioxidants (Basel, Switzerland), 9(6), 553. https://doi.org/10.3390/antiox9060553
dc.identifier.issn2076-3921
dc.identifier.issue6
dc.identifier.urihttps://hdl.handle.net/20.500.12503/31529
dc.identifier.volume9
dc.publisherMDPI
dc.relation.urihttps://doi.org/10.3390/antiox9060553
dc.rights.holderCopyright © 2020 by the authors.
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceAntioxidants
dc.subjectAlzheimer's disease
dc.subjectApoE
dc.subjectaging
dc.subjectantioxidants
dc.subjectcognition
dc.subjectexercise
dc.subjectmotor
dc.subjectvitamin C
dc.subjectvitamin E
dc.subject.meshAlzheimer Disease
dc.subject.meshOxidative Stress
dc.titleApoE Genotype-Dependent Response to Antioxidant and Exercise Interventions on Brain Function
dc.typeArticle
dc.type.materialtext

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