Key Signaling Pathways in Aging and Potential Interventions for Healthy Aging

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dc.creatorYu, Mengdi
dc.creatorZhang, Hongxia
dc.creatorWang, Brian
dc.creatorZhang, Yinuo
dc.creatorZheng, Xiaoying
dc.creatorShao, Bei
dc.creatorZhuge, Qichuan
dc.creatorJin, Kunlin
dc.creator.orcid0000-0002-1336-348X (Jin, Kunlin)
dc.creator.orcid0000-0003-1594-6707 (Zhang, Hongxia)
dc.date.accessioned2022-09-09T14:08:42Z
dc.date.available2022-09-09T14:08:42Z
dc.date.issued2021-03-16
dc.description.abstractAging is a fundamental biological process accompanied by a general decline in tissue function. Indeed, as the lifespan increases, age-related dysfunction, such as cognitive impairment or dementia, will become a growing public health issue. Aging is also a great risk factor for many age-related diseases. Nowadays, people want not only to live longer but also healthier. Therefore, there is a critical need in understanding the underlying cellular and molecular mechanisms regulating aging that will allow us to modify the aging process for healthy aging and alleviate age-related disease. Here, we reviewed the recent breakthroughs in the mechanistic understanding of biological aging, focusing on the adenosine monophosphate-activated kinase (AMPK), Sirtuin 1 (SIRT1) and mammalian target of rapamycin (mTOR) pathways, which are currently considered critical for aging. We also discussed how these proteins and pathways may potentially interact with each other to regulate aging. We further described how the knowledge of these pathways may lead to new interventions for antiaging and against age-related disease.
dc.description.sponsorshipThis research received no external funding.
dc.identifier.citationYu, M., Zhang, H., Wang, B., Zhang, Y., Zheng, X., Shao, B., Zhuge, Q., & Jin, K. (2021). Key Signaling Pathways in Aging and Potential Interventions for Healthy Aging. Cells, 10(3), 660. https://doi.org/10.3390/cells10030660
dc.identifier.issn2073-4409
dc.identifier.issue3
dc.identifier.urihttps://hdl.handle.net/20.500.12503/31700
dc.identifier.volume10
dc.publisherMDPI
dc.relation.urihttps://doi.org/10.3390/cells10030660
dc.rights.holder© 2021 by the authors.
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceCells
dc.subjectmetabolism
dc.subjectampk
dc.subjectsirt1
dc.subjectaging
dc.subjecthealth span
dc.subjectintervention
dc.subjectmTOR
dc.subjectsenescence
dc.subjectsignaling
dc.subject.meshAMP-Activated Protein Kinases / metabolism
dc.subject.meshAge Factors
dc.subject.meshAnimals
dc.subject.meshBiomarkers / metabolism
dc.subject.meshCognition / drug effects
dc.subject.meshCognitive Aging
dc.subject.meshEnzyme Activation
dc.subject.meshEnzyme Activators / therapeutic use
dc.subject.meshFunctional Status
dc.subject.meshHealthy Aging / drug effects
dc.subject.meshHealthy Aging / metabolism
dc.subject.meshHealthy Aging / psychology
dc.subject.meshHumans
dc.subject.meshMental Health
dc.subject.meshMolecular Targeted Therapy
dc.subject.meshProtein Kinase Inhibitors / therapeutic use
dc.subject.meshSignal Transduction / drug effects
dc.subject.meshSirtuin 1 / metabolism
dc.subject.meshTOR Serine-Threonine Kinases / antagonists & inhibitors
dc.subject.meshTOR Serine-Threonine Kinases / metabolism
dc.titleKey Signaling Pathways in Aging and Potential Interventions for Healthy Aging
dc.typeArticle
dc.type.materialtext

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