Anti-Tumor Immune Responses Against MTLn3 Mammary Adenocarcinoma

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dc.contributor.advisorHodge, Lisa M.
dc.creatorCarter, KiahRae J.
dc.date.accessioned2019-08-22T21:44:36Z
dc.date.available2019-08-22T21:44:36Z
dc.date.issued2014-05-01
dc.date.submitted2014-05-22T08:00:05-07:00
dc.description.abstractLymphatic pump treatment (LPT) is used as a lymph enhancing therapy to treat edema. In animals, LPT enhanced lymphatic flow, released leukocytes and inflammatory mediators into lymph, and inhibited pulmonary tumor formation. Therefore, we hypothesized the administration of LPT would enhance immunity and inhibit primary breast tumor growth. Rats were subcutaneously injected with MTLn3 and divided into MTLn3, MTLn3+Sham-LPT and MTLn3+LTP group. Sham group received light touch under anesthesia and LPT group received treatment under anesthesia. There were no changes in tumor growth between groups. Administration of Sham-LPT resulted in an increase in tumor-adjacent lymph node weight. Collectively, our data suggests LPT did not enhance primary tumor growth and may also protect against the pathogenesis exhibited by sham-LPT.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12503/29552
dc.language.isoen
dc.provenance.legacyDownloads1
dc.subjectHemic and Immune Systems
dc.subjectMedical Immunology
dc.subjectOsteopathic Medicine and Osteopathy
dc.subjectPhysical Therapy
dc.subjectPhysiotherapy
dc.subjectTherapeutics
dc.subjectBreast Cancer
dc.subjectLymphatic Pump Treatment
dc.subjectImmune Response
dc.titleAnti-Tumor Immune Responses Against MTLn3 Mammary Adenocarcinoma
dc.typeThesis
dc.type.materialtext
thesis.degree.disciplineBiomedical Sciences
thesis.degree.grantorUniversity of North Texas Health Science Center at Fort Worth
thesis.degree.nameMaster of Science

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