Acute Inflammatory Mediators in Young Adult Patients with COVID-19 in Mexico

Simple item page
dc.creatorMaldonado-Cabrera, Anahi
dc.creatorAngulo-Molina, Aracely
dc.creatorHaque, Ubydul
dc.creatorVelazquez, Carlos
dc.creatorAlvarez-Villasenor, Andrea S.
dc.creatorSantacruz-Gomez, Karla J.
dc.creatorGallego-Hernandez, Ana L.
dc.creator.orcid0000-0002-7413-1017 (Haque, Ubydul)
dc.date.accessioned2022-09-06T20:07:17Z
dc.date.available2022-09-06T20:07:17Z
dc.date.issued2021-08-20
dc.description.abstractYoung adults (18-40 years old) are an active population with high risk of infection and transmission of COVID-19. They are considered a low-risk population due to its low 1.0% case fatality rate (CFR). Despite their high clinical usefulness to prevent fatal cases, inflammatory and coagulation biomarkers studies are limited. For this reason, we performed a retrospective cohort study with COVID-19 patients in Hermosillo, Mexico, to assess inflammation, coagulopathy profile, and severity outcomes in young adults. We analyzed blood samples to determine the neutrophil/lymphocyte ratio (NLR), neutrophil/monocyte ratio (NMR), lymphocyte/monocyte ratio (LMR), platelet/lymphocyte ratio (PLR), and C-reactive protein (C-RP). We included epidemiological features and comorbidities, and compared them to the severity status. Only 359 COVID-19-confirmed young adults were included in the ambulatory (44.8%), hospitalized (42.9%), and death (12%) severity groups. Laboratory results showed an increase in NMR, LMR, and C-RP associated with the aggravated patients. Additionally, obesity, arterial hypertension, and type-2 diabetes mellitus (T2DM) were associated with the COVID-19 severity outcome. We found that 9.1% and 30.3% of young adults presented the novel COVID-19-associated coagulopathy (CAC) and the risk of CAC, respectively. These parameters can be considered independent biomarkers reflecting an enhanced inflammatory process related to the COVID-19 prognosis.
dc.description.sponsorshipWe acknowledge the Department of Chemical-Biological Science, the Division of Biological and Health Science, and the Division of Exact and Natural Science of the University of Sonora for their financial support to cover the publication fees of this article. UH was supported by the Research Council of Norway (Grant # 281077).
dc.identifier.citationMaldonado-Cabrera, A., Angulo-Molina, A., Haque, U., Velazquez, C., Álvarez-Villaseñor, A. S., Santacruz-Gómez, K. J., & Gallego-Hernández, A. L. (2021). Acute Inflammatory Mediators in Young Adult Patients with COVID-19 in Mexico. Pathogens (Basel, Switzerland), 10(8), 1056. https://doi.org/10.3390/pathogens10081056
dc.identifier.issn2076-0817
dc.identifier.issue8
dc.identifier.urihttps://hdl.handle.net/20.500.12503/31668
dc.identifier.volume10
dc.publisherMDPI
dc.relation.urihttps://doi.org/10.3390/pathogens10081056
dc.rights.holder© 2021 by the authors.
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourcePathogens
dc.subjectCovid-19
dc.subjectcoagulopathy
dc.subjecthematological profiles
dc.subjectyoung adults
dc.titleAcute Inflammatory Mediators in Young Adult Patients with COVID-19 in Mexico
dc.typeArticle
dc.type.materialtext

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
10.3390_pathogens10081056.pdf
Size:
1.54 MB
Format:
Adobe Portable Document Format
Description:
full text article
Download

Collections

Publications -- Ubydul Haque