Proteomic profiles for Alzheimer's disease and mild cognitive impairment among adults with Down syndrome spanning serum and plasma: An Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS) study

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dc.creatorPetersen, Melissa E.
dc.creatorZhang, Fan
dc.creatorSchupf, Nicole
dc.creatorKrinsky-McHale, Sharon J.
dc.creatorHall, James R.
dc.creatorMapstone, Mark
dc.creatorCheema, Amrita
dc.creatorSilverman, Wayne
dc.creatorLott, Ira
dc.creatorRafii, Michael S.
dc.creatorHanden, Benjamin
dc.creatorKlunk, William
dc.creatorHead, Elizabeth
dc.creatorChristian, Bradley
dc.creatorForoud, Tatiana
dc.creatorLai, Florence
dc.creatorRosas, H. Diana
dc.creatorZaman, Shahid
dc.creatorAnces, Beau M.
dc.creatorWang, Mei-Cheng
dc.creatorTycko, Benjamin
dc.creatorLee, Joseph H.
dc.creatorO'Bryant, Sid E.
dc.creator.orcid0000-0003-0582-5266 (O'Bryant, Sid E.)
dc.creator.orcid0000-0002-3920-5877 (Petersen, Melissa E.)
dc.date.accessioned2022-07-07T13:54:27Z
dc.date.available2022-07-07T13:54:27Z
dc.date.issued2020-06-30
dc.description.abstractIntroduction: Previously generated serum and plasma proteomic profiles were examined among adults with Down syndrome (DS) to determine whether these profiles could discriminate those with mild cognitive impairment (MCI-DS) and Alzheimer's disease (DS-AD) from those cognitively stable (CS). Methods: Data were analyzed on n = 305 (n = 225 CS; n = 44 MCI-DS; n = 36 DS-AD) enrolled in the Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS). Results: Distinguishing MCI-DS from CS, the serum profile produced an area under the curve (AUC) = 0.95 (sensitivity [SN] = 0.91; specificity [SP] = 0.99) and an AUC = 0.98 (SN = 0.96; SP = 0.97) for plasma when using an optimized cut-off score. Distinguishing DS-AD from CS, the serum profile produced an AUC = 0.93 (SN = 0.81; SP = 0.99) and an AUC = 0.95 (SN = 0.86; SP = 1.0) for plasma when using an optimized cut-off score. AUC remained unchanged to slightly improved when age and sex were included. Eotaxin3, interleukin (IL)-10, C-reactive protein, IL-18, serum amyloid A , and FABP3 correlated fractions at r2 > = 0.90. Discussion: Proteomic profiles showed excellent detection accuracy for MCI-DS and DS-AD.
dc.description.sponsorshipThis publication was supported by the National Center for Advancing Translational Sciences, National Institutes of Health, through Grant Number UL1TR001873. This work was also supported by grant IIRG-08-90655 from the Alzheimer's Association (Schupf, O'Bryant) and by additional grants P01HD035897 (Silverman) from National Institute for Child Health and Human Development (NICHD), and R01AG014673 (Schupf), R01AG058537 (O'Bryant), R01AG058252 (O'Bryant) and R01AG051848 (O'Bryant) from National Institute on Aging (NIA), and by NYS through its office for People with Developmental Disabilities.
dc.identifier.citationPetersen, M. E., Zhang, F., Schupf, N., Krinsky-McHale, S. J., Hall, J., Mapstone, M., Cheema, A., Silverman, W., Lott, I., Rafii, M. S., Handen, B., Klunk, W., Head, E., Christian, B., Foroud, T., Lai, F., Rosas, H. D., Zaman, S., Ances, B. M., Wang, M. C., Tycko B, Lee JH, O'Bryant S; Alzheimer's Biomarker Consortium – Down Syndrome (ABC-DS) (2020). Proteomic profiles for Alzheimer's disease and mild cognitive impairment among adults with Down syndrome spanning serum and plasma: An Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS) study. Alzheimer's & dementia (Amsterdam, Netherlands), 12(1), e12039. https://doi.org/10.1002/dad2.12039
dc.identifier.issn2352-8729
dc.identifier.issue1
dc.identifier.urihttps://hdl.handle.net/20.500.12503/31542
dc.identifier.volume12
dc.publisherWiley Periodicals, Inc.
dc.relation.urihttps://doi.org/10.1002/dad2.12039
dc.rights.holderCopyright © 2020 The Authors.
dc.rights.licenseAttribution-NonCommercial 4.0 International (CC BY-NC 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.sourceAlzheimer's & Dementia Diagnosis, Assessment & Disease Monitoring
dc.titleProteomic profiles for Alzheimer's disease and mild cognitive impairment among adults with Down syndrome spanning serum and plasma: An Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS) study
dc.typeArticle
dc.type.materialtext

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