Impact of age on technical and in-hospital outcomes of percutaneous coronary intervention for chronic total occlusions

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dc.contributor.advisorPatricia A. Gwirtz
dc.contributor.committeeMemberEmmanouil S. Brilakis
dc.contributor.committeeMemberMichael L. Smith
dc.creatorIwnetu, Rahel
dc.date.accessioned2019-08-22T21:44:09Z
dc.date.available2019-08-22T21:44:09Z
dc.date.issued2016-05-01
dc.date.submitted2017-10-13T14:11:30-07:00
dc.description.abstractBackground: We sought to examine the effect of patient age on the outcomes of percutaneous coronary intervention (PCI) of chronic total occlusions (CTO). Methods: We examined clinical and angiographic data as well as outcomes of 1,216 CTO PCIs performed in 1,195 patients divided into three age groups ([less than] 65, 65-75, and ≥75 years old). Results: Increasing age was associated with higher prevalence of prior stroke (7.6% vs 12.6% vs 17.2% for [less than] 65, 65-75, and ≥75 years old respectively, p [less than] 0.001) and prior coronary artery bypass graft surgery (25.2% vs 39.8% vs 45.5%, p [less than] 0.001), but lower prevalence of current smoking (36.4% vs 25.7% vs 14.6%, p [less than] 0.001). Older patients were also more likely to have hypertension (88.1% vs 88.7% vs 94.0%, p=0.042) and have moderately or severely calcified lesions (48.4% vs 59.8% vs 75.0%, p [less than] 0.001). Technical success rate was similar in all age groups (91.1% vs 90.7% vs 85.7%, p=0.054), but a higher incidence of major adverse cardiac events (MACE) was noted in the ≥75 years old group (0.9% vs 3.0% vs 5.1%, p=0.002), largely due to higher rate of cardiac tamponade requiring pericardiocentesis (0% vs 0.7% vs 2.2%, p=0.004). Procedure time, contrast volume and air kerma radiation dose did not differ significantly between the three groups. Conclusion: CTO PCI can be performed with high success rates among older patients, but may carry higher risk for complications in this patient group.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12503/29546
dc.language.isoen
dc.provenance.legacyDownloads51
dc.subjectMedical Sciences
dc.subjectMedicine and Health Sciences
dc.subjectchronic total occlusion
dc.subjectpercutaneous coronary intervention
dc.subjectcoronary artery disease
dc.titleImpact of age on technical and in-hospital outcomes of percutaneous coronary intervention for chronic total occlusions
dc.typeInternship Practicum Report
dc.type.materialtext
thesis.degree.departmentGraduate School of Biomedical Sciences
thesis.degree.disciplineClinical Research Management
thesis.degree.grantorUniversity of North Texas Health Science Center at Fort Worth
thesis.degree.nameMaster of Science

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