Assessment of Sex Differences Following Repeated Mild Head Injuries

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dc.contributor.advisorSchreihofer, Derek A.
dc.contributor.committeeMemberSumien, Nathalie
dc.contributor.committeeMemberLuedtke, Robert R.
dc.creatorDuggal, Aakaash
dc.date.accessioned2022-05-27T19:25:19Z
dc.date.available2022-05-27T19:25:19Z
dc.date.issued2022-05
dc.description.abstractThere is limited information about sex differences in mRHI, despite some studies suggesting females participating in contact sports experience more head injuries than males. This study will test the hypothesis that mRHI will lead to more severe neurological deficits in female mice than in male mice. C57BL/6 female mice were assigned to sham and mRHI groups (n=30/group). Lightly anesthetized mice received 25 mild head injuries, once a day (M-F) over 5 weeks using a weight drop model that included a free fall with rotational injury. Acutely, mRHI female mice performed worse than sham injured mice on the balance beam (F (1,28) =4.309, P=0.0472) whereas there was no difference in males. 5 weeks and 15 weeks after injury mice underwent a 3-week series of behavioral tests. Both male and female mice in the mRHI groups performed significantly (T-test P< 0.01) worse on the Rotarod than uninjured controls. Only males in MWM showed significant impairment on memory for 5-week and significant impairment on spatial learning and memory for 15-week (Probe T-test P< 0.05). Only 15-week male mice showed deficits in elevated plus maze (EPM) (T-test P< 0.05). Acutely, female mice showed balance deficits that were not apparent in males. Fifteen weeks after mRHI, males no longer displayed deficits in the rotarod, but female mice continued to have a decrease in performance compared to controls (T-test, P<0.05). Unlike the males, female mice did not display any significant deficits in the MWM and EPM.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12503/31167
dc.language.isoen
dc.subjecthead injury
dc.subjectmild head injury
dc.subjectrepeated head injury
dc.subjectmild repeated head injury
dc.subjecttraumatic brain injury
dc.subjectmild traumatic brain injury
dc.subjectrepetitive traumatic brain injury
dc.subjectrepeated mild traumatic brain injury
dc.subject.meshCraniocerebral Trauma
dc.subject.meshSex Characteristics
dc.subject.meshHead Injuries, Closed
dc.titleAssessment of Sex Differences Following Repeated Mild Head Injuries
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentGraduate School of Biomedical Sciences
thesis.degree.disciplinePharmacology and Neuroscience
thesis.degree.grantorUniversity of North Texas Health Science Center at Fort Worth
thesis.degree.nameMaster of Science

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