Strategy to Design a Stratified Corneal Stroma Construct

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dc.contributor.advisorDan Dimitrijevich
dc.contributor.committeeMemberIgnacy Gryczynski
dc.contributor.committeeMemberHarlan Jones
dc.creatorArafeh, Reem B.
dc.date.accessioned2019-08-22T21:18:00Z
dc.date.available2019-08-22T21:18:00Z
dc.date.issued2008-07-01
dc.date.submitted2013-11-18T12:54:15-08:00
dc.description.abstractArafeh, Reem B., Strategy to Design a Stratified Lamellar Corneal Stroma Construct. Master of Science (Biomedical Sciences), July 2nd, 2008, 103pp., 1 table, 42 illustrations, bibliography, 63 titles. Cornea is the transparent portion of the eye. Its three cellular compartments: the epithelium, stroma, and endothelium, are optimized for transparency and focusing. Although corneal grafting with donor corneas is a successful treatment to restore vision, there is an acute shortage of appropriate quality donor tissue. Tissue engineering is a new approach that addresses this shortage. In this thesis it was demonstrated that lamellar stromal structure is reproduced by stacking thin collagen films. Collagen fibril organization in the thin films directs cellular alignment allowing assembly of an orthogonal stroma construct that transmits more light than most other published constructs and is optically active. Whereas the cell alignment and lamellar arrangement were successful, optimization of optical properties is a major future goal.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12503/29226
dc.language.isoen
dc.provenance.legacyDownloads2
dc.subjectCell Anatomy
dc.subjectCell and Developmental Biology
dc.subjectCell Biology
dc.subjectCellular and Molecular Physiology
dc.subjectDevelopmental Biology
dc.subjectEye Diseases
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.subjectOphthalmology
dc.subjectOptometry
dc.subjectOther Cell and Developmental Biology
dc.subjectSense Organs
dc.subjectVision Science
dc.subjectStratified lamellar corneal stroma construct
dc.subjectepithelium
dc.subjectstroma
dc.subjectendothelium
dc.subjectcorneal grafting
dc.subjecttissue engineering
dc.subjectcollagen fibril organization
dc.subjectcellular alignment
dc.subjectorthogonal stroma construct
dc.subjectoptimization of optical properties
dc.titleStrategy to Design a Stratified Corneal Stroma Construct
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentGraduate School of Biomedical Sciences
thesis.degree.disciplineBiomedical Sciences
thesis.degree.grantorUniversity of North Texas Health Science Center at Fort Worth
thesis.degree.nameMaster of Science

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