Distinct Roles of mTOR Targets S6K1 and S6K2 in Breast Cancer

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dc.creatorSridharan, Savitha
dc.creatorBasu, Alakananda
dc.creator.orcid0000-0002-1656-0788 (Basu, Alakananda)
dc.date.accessioned2022-08-22T18:10:30Z
dc.date.available2022-08-22T18:10:30Z
dc.date.issued2020-02-11
dc.description.abstractThe mechanistic target of rapamycin (mTOR) is a master regulator of protein translation, metabolism, cell growth and proliferation. It forms two complexes, mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 is frequently deregulated in many cancers, including breast cancer, and is an important target for cancer therapy. The immunosuppressant drug rapamycin and its analogs that inhibit mTOR are currently being evaluated for their potential as anti-cancer agents, albeit with limited efficacy. mTORC1 mediates its function via its downstream targets 40S ribosomal S6 kinases (S6K) and eukaryotic translation initiation factor 4E (eIF4E)-binding protein 1 (4E-BP1). There are two homologs of S6K: S6K1 and S6K2. Most of the earlier studies focused on S6K1 rather than S6K2. Because of their high degree of structural homology, it was generally believed that they behave similarly. Recent studies suggest that while they may share some functions, they may also exhibit distinct or even opposite functions. Both homologs have been implicated in breast cancer, although how they contribute to breast cancer may differ. The purpose of this review article is to compare and contrast the expression, structure, regulation and function of these two S6K homologs in breast cancer.
dc.identifier.citationSridharan, S., & Basu, A. (2020). Distinct Roles of mTOR Targets S6K1 and S6K2 in Breast Cancer. International journal of molecular sciences, 21(4), 1199. https://doi.org/10.3390/ijms21041199
dc.identifier.issn1422-0067
dc.identifier.issue4
dc.identifier.urihttps://hdl.handle.net/20.500.12503/31596
dc.identifier.volume21
dc.publisherMDPI
dc.relation.urihttps://doi.org/10.3390/ijms21041199
dc.rights.holder© 2020 by the authors.
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceInternational Journal of Molecular Sciences
dc.subjectRps6kb1
dc.subjectRps6kb2
dc.subjectS6k1
dc.subjectS6k2
dc.subjectbreast cancer
dc.subjectmTOR
dc.subject.meshAnimals
dc.subject.meshBreast Neoplasms / genetics
dc.subject.meshBreast Neoplasms / metabolism
dc.subject.meshBreast Neoplasms / pathology
dc.subject.meshEnzyme Activation
dc.subject.meshFemale
dc.subject.meshGene Amplification
dc.subject.meshGene Expression Regulation, Neoplastic
dc.subject.meshHumans
dc.subject.meshProtein Interaction Maps
dc.subject.meshRibosomal Protein S6 Kinases, 70-kDa / analysis
dc.subject.meshRibosomal Protein S6 Kinases, 70-kDa / genetics
dc.subject.meshRibosomal Protein S6 Kinases, 70-kDa / metabolism
dc.subject.meshTOR Serine-Threonine Kinases / analysis
dc.subject.meshTOR Serine-Threonine Kinases / genetics
dc.subject.meshTOR Serine-Threonine Kinases / metabolism
dc.titleDistinct Roles of mTOR Targets S6K1 and S6K2 in Breast Cancer
dc.typeArticle
dc.type.materialtext

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