Should Renal Inflammation Be Targeted While Treating Hypertension?

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dc.creatorChaudhari, Sarika
dc.creatorPham, Grace S.
dc.creatorBrooks, Calvin D.
dc.creatorDinh, Viet Q.
dc.creatorYoung-Stubbs, Cassandra M.
dc.creatorShimoura, Caroline G.
dc.creatorMathis, Keisa W.
dc.date.accessioned2022-10-14T16:48:29Z
dc.date.available2022-10-14T16:48:29Z
dc.date.issued2022-06-13
dc.description.abstractDespite extensive research and a plethora of therapeutic options, hypertension continues to be a global burden. Understanding of the pathological roles of known and underexplored cellular and molecular pathways in the development and maintenance of hypertension is critical to advance the field. Immune system overactivation and inflammation in the kidneys are proposed alternative mechanisms of hypertension, and resistant hypertension. Consideration of the pathophysiology of hypertension in chronic inflammatory conditions such as autoimmune diseases, in which patients present with autoimmune-mediated kidney inflammation as well as hypertension, may reveal possible contributors and novel therapeutic targets. In this review, we 1) summarize current therapies used to control blood pressure and their known effects on inflammation; 2) provide evidence on the need to target renal inflammation, specifically, and especially when first-line and combinatory treatment efforts fail; and 3) discuss the efficacy of therapies used to treat autoimmune diseases with a hypertension/renal component. We aim to elucidate the potential of targeting renal inflammation in certain subsets of patients resistant to current therapies.
dc.description.sponsorshipFunded by R01HL153703, K01HL139859 and a seed grant from the UNTHSC, Department of Physiology to KWM; T32AG020494 to CDB.
dc.identifier.citationChaudhari, S., Pham, G. S., Brooks, C. D., Dinh, V. Q., Young-Stubbs, C. M., Shimoura, C. G., & Mathis, K. W. (2022). Should Renal Inflammation Be Targeted While Treating Hypertension?. Frontiers in physiology, 13, 886779. https://doi.org/10.3389/fphys.2022.886779
dc.identifier.issn1664-042X
dc.identifier.urihttps://hdl.handle.net/20.500.12503/31874
dc.identifier.volume13
dc.publisherFrontiers Media S.A.
dc.relation.urihttps://doi.org/10.3389/fphys.2022.886779
dc.rights.holder© 2022 Chaudhari, Pham, Brooks, Dinh, Young-Stubbs, Shimoura and Mathis.
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceFrontiers in Physiology
dc.subjectautoimmunity
dc.subjectblood pressure
dc.subjectimmune cells
dc.subjectkidney
dc.subjectlupus
dc.subjectresistant hypertension
dc.subjectsystemic lupus erythematosus
dc.titleShould Renal Inflammation Be Targeted While Treating Hypertension?
dc.typeArticle
dc.type.materialtext

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