Establishment of Animal Models of Mycoplasma pnumoniae pneumonia and Staphylococcus arueus osteomyelitis

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dc.contributor.advisorSimecka, Jerry W.
dc.contributor.committeeMemberBerg, Rance E.
dc.contributor.committeeMemberJones, Harlan P.
dc.contributor.committeeMemberPark, InWoo
dc.contributor.committeeMemberReeves, Rustin E.
dc.creatorChikelue, Calvin I.
dc.date.accessioned2019-12-02T17:05:59Z
dc.date.available2019-12-02T17:05:59Z
dc.date.issued2018-12
dc.description.abstractAnimal models are useful tools in the study and development of clinical solutions to pathogens. Our focus is on two clinically relevant bacterium: Mycoplama pnumoniae which can lead to community acquired pneumonia and Staphylococcus aureus which can result in osteomyelitis. We formed experimental designs to establish murine models for these pathogens. By testing multiple strains of mycoplasma within mice, infecting both immunocompetent and immunodeficient mice as well as humanized mice, we have begun the preliminary development of a humanized mouse model for M. pneumoniae. As well, by testing multiple strains of S. aureus and their ability to both attach to and from biofilm on orthopedic pins, we've developed the first steps toward a murine model for S. aureus Osteomyelitis.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12503/29757
dc.language.isoen
dc.subjectmouse model
dc.subjectosteomyelitis
dc.subjectpneumonia
dc.subjectStapylococcus aureus
dc.subject.meshMycoplasma pneumoniae/pathogenicity
dc.subject.meshMurine pneumonia virus/pathogenicity
dc.subject.meshDisease Models, Animal
dc.subject.meshOsteomyelitis
dc.subject.meshStaphylococcus aureus/pathogenicity
dc.titleEstablishment of Animal Models of Mycoplasma pnumoniae pneumonia and Staphylococcus arueus osteomyelitis
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentGraduate School of Biomedical Sciences
thesis.degree.disciplineMicrobiology and Immunology
thesis.degree.grantorUniversity of North Texas Health Science Center at Fort Worth
thesis.degree.nameMaster of Science

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