Population-Specific mtDNA Indices of Mitochondrial Stress Associated with Alzheimer's Disease in Mexican Americans and Non-Hispanic Whites

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dc.contributor.advisorPhillips, Nicole R.
dc.contributor.committeeMemberBarber, Robert C.
dc.contributor.committeeMemberJones, Harlan P.
dc.creatorGorham, Isabelle K.
dc.date.accessioned2024-06-04T19:40:02Z
dc.date.available2024-06-04T19:40:02Z
dc.date.issued2023-05
dc.description.abstractAge is known to be the biggest risk factor for Alzheimer's disease (AD), and Mexican Americans (MAs) are the fastest-aging ethnic group in America. This puts MAs at a uniquely elevated risk for AD. This study aimed to identify ethnicity-specific markers for mitochondrial dysfunction associated with cognitive decline and detectable in peripheral blood cells (PBMCs). Specifically, copy numbers of mtDNA and nuclear DNA in PBMCs and blood plasma from non-Hispanic white and Mexican American participants were assessed by qPCR as potential markers of mitochondrial dysfunction and increased risk for cognitive decline. Evidence from these experiments shows that there are ethnicity-specific markers for this blood-based phenotype of mitochondrial dysfunction, which may also be indicative of an increased risk for cognitive decline and Alzheimer's disease.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12503/32829
dc.language.isoen
dc.subjectAlzheimer's disease
dc.subjectmitochondrial stress
dc.subjectmtDNA
dc.subjecthealth disparities
dc.subject.meshAlzheimer Disease
dc.subject.meshHealth Inequities
dc.subject.meshDNA, Mitochondrial
dc.titlePopulation-Specific mtDNA Indices of Mitochondrial Stress Associated with Alzheimer's Disease in Mexican Americans and Non-Hispanic Whites
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentSchool of Biomedical Sciences
thesis.degree.grantorUniversity of North Texas Health Science Center at Fort Worth
thesis.degree.nameMaster of Science

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