The Impact of the Mycoplasma pulmonis MALP-2 Homologue on Disease Progression

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dc.contributor.advisorSimecka, Jerry W.
dc.contributor.committeeMemberHodge, Lisa M.
dc.contributor.committeeMemberMathew, Porunelloor A.
dc.creatorSpear, Marcia G.
dc.date.accessioned2019-08-22T20:07:08Z
dc.date.available2019-08-22T20:07:08Z
dc.date.issued2008-04-01
dc.date.submitted2014-04-01T09:12:05-07:00
dc.description.abstractSpear, Marcia. The Impact of Mycoplasma pulmonis MALP-2 Homologue on Disease Progression. Master of Science (Biomedical Sciences), April 2008. 64 pp., 3 tables, 8 illustrations. Using Mycoplasma pulmonis, this project looked at a possible critical component in mycoplasma disease, the MALP-2 homologue lipoprotein. Studies demonstrated other lipoproteins besides the MALP-2 homologue were critical for in vivo disease progression and in vitro macrophage IL-6, IL-12, and TNF-α cytokine production. This trend was also seen human endothelial kidney (HEK) cells transfected with toll-like receptor 1 (TLR2) and the heterodimer TLR2/6. An increase in IL-8 cytokine production seen in all stimulated HEK cell lines, indicating the lipoproteins involved in cell interactions are TLR2 mediated. This project suggests the M. pulmonis MALP-2 homologue is not the main lipoprotein involved in disease progression and cell interactions, indicating the MALP-2 homologue may not be an ideal target for vaccines or antibiotics.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12503/27835
dc.language.isoen
dc.provenance.legacyDownloads0
dc.subjectBacteria
dc.subjectBacterial Infections and Mycoses
dc.subjectCell Anatomy
dc.subjectCell and Developmental Biology
dc.subjectCell Biology
dc.subjectCells
dc.subjectCellular and Molecular Physiology
dc.subjectDevelopmental Biology
dc.subjectDiseases
dc.subjectImmunology and Infectious Disease
dc.subjectLife Sciences
dc.subjectMedical Cell Biology
dc.subjectMedical Microbiology
dc.subjectMedical Molecular Biology
dc.subjectMedicine and Health Sciences
dc.subjectOther Cell and Developmental Biology
dc.subjectVirus Diseases
dc.subjectMycoplasma pulmonis
dc.subjectMALP-2
dc.subjecthomologue
dc.subjectdisease progression
dc.subjectimpact
dc.subjectbiomedical science
dc.subjectmycoplasma disease
dc.subjectlipoprotein
dc.subjectin vivo disease progression
dc.subjectin vitro macrophage
dc.subjectIL-6
dc.subjectIL-12
dc.subjectTNF-α cytokine
dc.subjecthuman endothelial kidney cells
dc.subjectM. pulmonis
dc.subjectcell interaction
dc.subjectvaccines
dc.subjectantibiotics
dc.titleThe Impact of the Mycoplasma pulmonis MALP-2 Homologue on Disease Progression
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentGraduate School of Biomedical Sciences
thesis.degree.disciplineBiomedical Sciences
thesis.degree.grantorUniversity of North Texas Health Science Center at Fort Worth
thesis.degree.nameMaster of Science

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