A Study of the Effectiveness and Tolerability of Weekly Rifapentine/Isoniazid for Three Months Versus Daily Isoniazid for Nine Months for the Treatment of Latent Tuberculosis Infection

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dc.contributor.advisorPatricia Gwirtz
dc.contributor.committeeMemberWalter McConathy
dc.contributor.committeeMemberRichard Easom
dc.creatorLemp, Jessie
dc.date.accessioned2019-08-22T21:34:21Z
dc.date.available2019-08-22T21:34:21Z
dc.date.issued2004-11-01
dc.date.submitted2014-05-30T08:00:05-07:00
dc.description.abstractLemp, Jessie M. A Study of the Effectiveness and Tolerability of Weekly Rifapentine/Isoniazid for Three Months Versus Daily Isoniazid for Nine Months for the Treatment of Latent Tuberculosis Infection. Master of Science, November, 2004, 107 pp., 4 tables, 4 figures, references, 29 titles. The standard treatment for latent tuberculosis infection, nine months of daily isoniazid, is effective at preventing active tuberculosis; however, its full benefits are limited by non-adherence. A shorter intermittent regimen of rifapentine plus isoniazid once weekly for three months is equally effective as the standard regimen in animal models. This regimen facilitates the use of directly observed therapy, a method that significantly improves adherence. The Center for Disease Control is sponsoring Study 26 to test the effectiveness and tolerability the three-month rifapentine based regimen in latently infected persons with risk factors for progression to active tuberculosis. This thesis will describe the background rationale and methods for the clinical trial, and the internship experience.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12503/29431
dc.language.isoen
dc.provenance.legacyDownloads0
dc.subjectBacteria
dc.subjectBacterial Infections and Mycoses
dc.subjectChemicals and Drugs
dc.subjectDiseases
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.subjectOther Pharmacy and Pharmaceutical Sciences
dc.subjectPharmaceutical Preparations
dc.subjectPharmacy and Pharmaceutical Sciences
dc.subjectRespiratory System
dc.subjectRespiratory Tract Diseases
dc.subjectEffectiveness
dc.subjecttolerability
dc.subjectrifapentine
dc.subjectisoniazid
dc.subjectlatent tuberculosis infection
dc.subjecttreatment
dc.subjectCDC
dc.subjectCenter for Disease Control
dc.subjectregimen
dc.subjectclinical trial
dc.subjectinternship
dc.titleA Study of the Effectiveness and Tolerability of Weekly Rifapentine/Isoniazid for Three Months Versus Daily Isoniazid for Nine Months for the Treatment of Latent Tuberculosis Infection
dc.typeProfessional Report
dc.type.materialtext
thesis.degree.departmentGraduate School of Biomedical Sciences
thesis.degree.disciplineClinical Research Management
thesis.degree.grantorUniversity of North Texas Health Science Center at Fort Worth
thesis.degree.nameMaster of Science

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