Evaluating Noise and the Implications of Methodology in the Analytical Threshold Designation for Forensic Genetic Analysis

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dc.contributor.advisorJoseph E. Warren
dc.contributor.committeeMemberJohn V. Planz
dc.contributor.committeeMemberRaghu R. Krishnamoorthy
dc.creatorMalone, Ashley N.
dc.date.accessioned2019-08-22T20:39:41Z
dc.date.available2019-08-22T20:39:41Z
dc.date.issued2015-08-01
dc.date.submitted2015-08-17T12:36:05-07:00
dc.description.abstractIt is common in the forensic science community to have standardization and uniformity in all laboratory processes. The method for the determination of a minimum detection threshold or synonymously an analytical threshold for genetic analysis is not uniform across forensic labs. Variation amongst the methods in DNA testing by forensic laboratories leads to variations in the results of the DNA testing. The results of this study show a method using DNA sample types versus non-DNA sample types will better reflect the effects of baseline noise that may be encountered in forensic casework samples. In addition, there is a need for a calculation method to be designated as an appropriate tool in determining analytical thresholds. More studies on baseline noise and methods in distinguishing analytical thresholds will help in the determination of the most appropriate calculation method to be used across all forensic laboratories.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12503/28635
dc.language.isoen
dc.provenance.legacyDownloads102
dc.subjectForensic Science and Technology
dc.subjectGenetics and Genomics
dc.subjectInvestigative Techniques
dc.subjectLaboratory and Basic Science Research
dc.subjectMedical Sciences
dc.subjectMedicine and Health Sciences
dc.subjectNucleic Acids, Nucleotides, and Nucleosides
dc.subjectbaseline noise
dc.subjectanalytical threshold
dc.subjectDNA analysis
dc.subjectforensic science
dc.titleEvaluating Noise and the Implications of Methodology in the Analytical Threshold Designation for Forensic Genetic Analysis
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentGraduate School of Biomedical Sciences
thesis.degree.disciplineForensic Genetics
thesis.degree.grantorUniversity of North Texas Health Science Center at Fort Worth
thesis.degree.nameMaster of Science

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