ANTIOXIDANT COMPOUNDS INHIBIT COCAINE-CONDITIONED LOCOMOTION
| dc.creator | Nguyen, Jacques | |
| dc.date.accessioned | 2022-07-05T15:05:20Z | |
| dc.date.available | 2022-07-05T15:05:20Z | |
| dc.date.issued | 2013-04-12 | |
| dc.description.abstract | Purpose: Cocaine, a potent psychostimulant, produces various neuroadaptations that further contribute to its overall abuse. Although there currently are no known pharmacological treatments for cocaine addiction, N-acetylcysteine, a thiol-containing antioxidant, has been shown to prevent relapse in animal models of cocaine-addiction and to effect drug reward value following psychostimulant toxicity. This study evaluates the mechanisms that underlie this compound's ability to affect cocaine-conditioned locomotion and compares its efficacy to other potential intervention(s) for cocaine-induced effects. Methods: Cocaine (40mg/kg) and 0.9% saline were administered to Swiss-Webster mice via intraperitoneal injection (i.p.), in either the testing apparatus or the home cage, separated by a 2-hour time interval. When the animals were placed into the testing chambers, they were given 30 minutes to explore freely and spontaneous locomotion was monitored using Digiscan animal tracking software. On the following day, N-acetylcysteine (25, 50, 100 mg/kg), dimethylthiourea (5, 10, 25, 50 mg/kg), or vehicle control were administered prior to placement into the activity chambers. Cocaine conditioned effect was inferred by a change in horizontal activity counts, respective to controls. Results: N-acetylcysteine (100mg/kg) and dimethylthiourea (25 and 50mg/kg) successfully inhibited cocaine-conditioned locomotion. Conclusions: N-acetylcysteine and dimethylthiourea's common ability to inhibit the cocaine-conditioned locomotion suggests that pro-oxidating cellular redox state may underlie acute neuroadaptations that occur during cocaine exposure. Understanding the nature of cocaine-conditioned effects, using various pharmacological interventions, may further provide insight into the molecular mechanisms underlying these drug-induced behaviors. | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12503/31408 | |
| dc.subject | cocaine | |
| dc.subject | conditioning | |
| dc.subject | antioxidant | |
| dc.title | ANTIOXIDANT COMPOUNDS INHIBIT COCAINE-CONDITIONED LOCOMOTION | |
| dc.type | presentation | |
| dc.type.material | text |