Chronic sleep restriction association with oral microbiome profile

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2020

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Trinh, Heather

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Abstract

Reduced sleep quality is a common problem in the United States. Inadequate sleep is linked to increased risk for several conditions, such as cardiovascular disease and Alzheimer's disease. Current evidence indicates an association between the gut microbiome and sleep modulation. Based on this relationship, we investigated whether changes in the gut microbiome of chronically sleep-restricted subjects were reflected in their oral microbiome. With the ease of access to the oral cavity for examination and sampling, correlations between the gut and oral microbiome have clinical implications for developing screening tools. Mice models were placed on chronic sleep restriction for six weeks via the Modified Multiple Platform Method. Oral swabs and tissue samples were collected at the end of this scheduled period and characterized using Miseq for sequencing the V4 region of the 16S rRNA gene.

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