Estrogen administration attenuates post-stroke depression by enhancing CREB/BDNF/TrkB signaling in the rat hippocampus

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dc.creatorJiang, Huigang
dc.creatorXiao, Li
dc.creatorJin, Kunlin
dc.creatorShao, Bei
dc.creator.orcid0000-0002-1336-348X (Jin, Kunlin)
dc.date.accessioned2022-09-09T14:08:41Z
dc.date.available2022-09-09T14:08:41Z
dc.date.issued2021-02-26
dc.description.abstractA previous study demonstrated that 17beta-estradiol (E2), which is an antidepressant, can ameliorate post-stroke depression (PSD); however, the underlying mechanisms governing this remain largely unknown. Therefore, the present study developed a PSD model in rats, which was induced by left middle cerebral artery occlusion followed by exposure to chronic mild stress for 2 weeks. The results revealed that the activity of the cAMP response element-binding protein (CREB), a cellular transcription factor, and the associated brain-derived neurotrophic factor (BDNF)/tyrosine kinase B (TrkB) signaling were all attenuated in the hippocampus in PSD rats. The depression-like behaviors were significantly improved after treatment with E2, along with increased CREB and the BDNF/TrkB signaling activity. These results provide novel insight into the molecular basis of PSD, and suggest the potential involvement of CREB/BDNF/TrkB signaling in E2-mediated improvement of PSD in rats.
dc.description.sponsorshipThe current study was supported by grants from Wenzhou Technology Foundation (grant no. H20090067) and the National Institute of Health (nos. AG21980 and NS057186).
dc.identifier.citationJiang, H., Xiao, L., Jin, K., & Shao, B. (2021). Estrogen administration attenuates post-stroke depression by enhancing CREB/BDNF/TrkB signaling in the rat hippocampus. Experimental and therapeutic medicine, 21(5), 433. https://doi.org/10.3892/etm.2021.9850
dc.identifier.issn1792-0981
dc.identifier.issue5
dc.identifier.urihttps://hdl.handle.net/20.500.12503/31694
dc.identifier.volume21
dc.publisherSpandidos Publications
dc.relation.urihttps://doi.org/10.3892/etm.2021.9850
dc.rights.holder© Jiang et al.
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceExperimental and Therapeutic Medicine
dc.subjectbrain-derived neurotrophic factor
dc.subjectcAMP response element-binding protein
dc.subjectdepression
dc.subjectestrogen
dc.subjecthippocampus
dc.subjectstroke
dc.subjecttyrosine kinase B
dc.titleEstrogen administration attenuates post-stroke depression by enhancing CREB/BDNF/TrkB signaling in the rat hippocampus
dc.typeArticle
dc.type.materialtext

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