The vascular aging of the cerebellum

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dc.contributor.advisorSumien, Nathalie
dc.contributor.committeeMemberSingh, Meharvan
dc.contributor.committeeMemberCunningham, J. Thomas
dc.creatorMcElroy, Christopher L.
dc.date.accessioned2019-08-22T20:30:36Z
dc.date.available2019-08-22T20:30:36Z
dc.date.issued2017-08-01
dc.date.submitted2017-10-13T13:06:14-07:00
dc.description.abstractThe cerebellum has been discovered to have an increased role in our daily lives than was previously recognized. It not controls fine motor skills, posture, and gait, but newer research has shown that it has a role in cognitive thought, memory and emotion, as well as other non-motor specific functions. It is important to know how this part of the brain ages and why. It is well established that during the aging process the cerebellum in some regions decreases in size due to atrophy, but the reasoning for this is not well understood. One possible mechanism that could explain the physical functional deficits contributed to the aging cerebellum is the aging of the vasculature in the cerebellum. We propose that there are changes to the surface area, volume, length, diameter, and branching of the blood vessels between young and aged C57/B6 black mice, specifically in the vermis and Crus I/II areas. These two areas are especially susceptible to the morphological changes caused by aging. To observe these changes traditional fluorescence and a new technique called Clarity will be implemented to evaluate the structural changes of the vessels in the cerebellum, and laser Doppler flowmetry will be used to evaluate the functional changes. Our hypothesis is that aging will cause a decrease in the surface area, volume, length, diameter, branching, and blood flow. What was observed was that there were not any significant changes to any of these parameters.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12503/28458
dc.language.isoen
dc.provenance.legacyDownloads12
dc.subjectMedical Sciences
dc.subjectMedicine and Health Sciences
dc.subjectaging
dc.subjectvascular
dc.subjectcerebellum
dc.subjectdisease
dc.subjectfunction
dc.subjectstructure
dc.subjectvasculature
dc.subjectcerebellar vermis
dc.titleThe vascular aging of the cerebellum
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentGraduate School of Biomedical Sciences
thesis.degree.disciplinePharmacology and Neuroscience
thesis.degree.grantorUniversity of North Texas Health Science Center at Fort Worth
thesis.degree.nameMaster of Science

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