Involvement of Nrf2 in Ocular Diseases
Date
2017-03-27
Authors
Batliwala, Shehzad
Xavier, Christy
Liu, Yang
Wu, Hongli
Pang, Iok-Hou
ORCID
0000-0002-0214-0352 (Xavier, Christy)
Journal Title
Journal ISSN
Volume Title
Publisher
Hindawi
Abstract
The human body harbors within it an intricate and delicate balance between oxidants and antioxidants. Any disruption in this checks-and-balances system can lead to harmful consequences in various organs and tissues, such as the eye. This review focuses on the effects of oxidative stress and the role of a particular antioxidant system-the Keap1-Nrf2-ARE pathway-on ocular diseases, specifically age-related macular degeneration, cataracts, diabetic retinopathy, and glaucoma. Together, they are the major causes of blindness in the world.
Description
Keywords
Animals, Eye Diseases / genetics, Eye Diseases / metabolism, Eye Diseases / pathology, Humans, Kelch-Like ECH-Associated Protein 1 / genetics, Kelch-Like ECH-Associated Protein 1 / metabolism, NF-E2-Related Factor 2 / genetics, NF-E2-Related Factor 2 / metabolism, Oxidation-Reduction, Oxidative Stress, Signal Transduction
Citation
Batliwala, S., Xavier, C., Liu, Y., Wu, H., & Pang, I. H. (2017). Involvement of Nrf2 in Ocular Diseases. Oxidative medicine and cellular longevity, 2017, 1703810. https://doi.org/10.1155/2017/1703810