Involvement of Nrf2 in Ocular Diseases

Date

2017-03-27

Authors

Batliwala, Shehzad
Xavier, Christy
Liu, Yang
Wu, Hongli
Pang, Iok-Hou

ORCID

0000-0002-0214-0352 (Xavier, Christy)

Journal Title

Journal ISSN

Volume Title

Publisher

Hindawi

Abstract

The human body harbors within it an intricate and delicate balance between oxidants and antioxidants. Any disruption in this checks-and-balances system can lead to harmful consequences in various organs and tissues, such as the eye. This review focuses on the effects of oxidative stress and the role of a particular antioxidant system-the Keap1-Nrf2-ARE pathway-on ocular diseases, specifically age-related macular degeneration, cataracts, diabetic retinopathy, and glaucoma. Together, they are the major causes of blindness in the world.

Description

Citation

Batliwala, S., Xavier, C., Liu, Y., Wu, H., & Pang, I. H. (2017). Involvement of Nrf2 in Ocular Diseases. Oxidative medicine and cellular longevity, 2017, 1703810. https://doi.org/10.1155/2017/1703810

Rights

© 2017 Shehzad Batliwala et al.

License

Attribution 4.0 International (CC BY 4.0)