Retrospective analysis of phase 3 clinical trial to evaluate the efficacy of drug B in anemia secondary to chronic kidney disease

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dc.contributor.advisorMathew, Stephen O.
dc.contributor.committeeMemberBasha, Riyaz
dc.creatorPollard, Kellyn
dc.date.accessioned2020-12-09T14:09:22Z
dc.date.available2020-12-09T14:09:22Z
dc.date.issued2019-12
dc.description.abstractTo evaluate the hemoglobin (Hb) levels in 18 patients with anemia secondary to chronic kidney disease, the safety and efficacy of Drug B (HIF-PH inhibitor) was compared to the standard of care. The purpose was to assess whether Drug B improved baseline Hb levels after 52 weeks and evaluate adverse events (AEs) and total supplementation. Retrospective analysis of Hb values and supplemental treatments were analyzed to determine the efficacy of Drug B and AEs were assessed to determine safety. Overall, Drug B was effective at increasing Hb levels and had less AEs but required more supplementation. The efficacy of Drug B as it relates to pharmacokinetics still needs to be investigated.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12503/29949
dc.language.isoen
dc.subjectphase 3 clinical trial
dc.subjectsecondary anemia
dc.subjectchronic kidney disease
dc.subject.meshRenal Insufficiency, Chronic
dc.subject.meshAnemia
dc.subject.meshClinical Trial, Phase III
dc.titleRetrospective analysis of phase 3 clinical trial to evaluate the efficacy of drug B in anemia secondary to chronic kidney disease
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentGraduate School of Biomedical Sciences
thesis.degree.disciplineClinical Research Management
thesis.degree.grantorUniversity of North Texas Health Science Center at Fort Worth
thesis.degree.nameMaster of Science

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