Genetic Modulation of β-Amyloid Neurotoxicity and Protection by Nicotinic Agents

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dc.contributor.advisorBasu, Alakananda
dc.contributor.committeeMemberForster, Michael
dc.contributor.committeeMemberSingh, Meharvan
dc.creatorMartin, Shelley E.
dc.date.accessioned2019-08-22T21:34:09Z
dc.date.available2019-08-22T21:34:09Z
dc.date.issued2007-05-01
dc.date.submitted2014-02-24T14:54:05-08:00
dc.description.abstractMartin, Shelley E., Genetic Modulation of β-Amyloid Neurotoxicity and Protection by Nicotinic Agents. Master of Science (Pharmacology and Neuroscience), May, 2007, 53 pp., 7 figures, 2 tables, bibliography, 95 titles. Β-amyloid1-42 (Aβ42) has been implicated in the pathogenesis of Alzheimer’s disease (AD); however, the amount of this peptide in the brain does not correlate well with the presence or severity of AD. This project tested the hypothesis that individual differences exist in susceptibility to Aβ42 neurotoxicity arising from the differences in the expression of α7 nicotinic acetylcholine receptors α7 nACHRs). This hypothesis was tested in primary neuronal cultures derived from inbred mouse strains which differ in expression of α7 nAChRs. Also, the ability of nicotinic agents to modulate Aβ42 toxicity was examined. Significant strain differences in susceptibility to Aβ42 toxicity were found; however, these were not related to levels of α7 nAChRs. Additionally, strain differences were found in the ability of α7-selective partial agonist, an α7-selective antagonist and a α4β2 nAChR-selective antagonist to protect against this toxicity. Inbred strains of mice may be useful in uncovering the pathophysiology of AD.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12503/29429
dc.language.isoen
dc.provenance.legacyDownloads1
dc.subjectLife Sciences
dc.subjectMedical Neurobiology
dc.subjectMedical Pharmacology
dc.subjectMedicine and Health Sciences
dc.subjectNervous System Diseases
dc.subjectNeuroscience and Neurobiology
dc.subjectOther Neuroscience and Neurobiology
dc.subjectPharmacology
dc.subjectGenetic modulation
dc.subjectβ-amyloid neurotoxicity
dc.subjectbeta-amyloid neurotoxicity
dc.subjectnicotinic agents
dc.subjectprotection
dc.subjectAβ42
dc.subjectAlzheimer’s Disease
dc.subjectpeptide
dc.subjectα7 nicotinic acetylcholine
dc.subjectnAChRs
dc.subjectmice
dc.subjectpathophysiology
dc.titleGenetic Modulation of β-Amyloid Neurotoxicity and Protection by Nicotinic Agents
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentGraduate School of Biomedical Sciences
thesis.degree.disciplinePharmacology and Neuroscience
thesis.degree.grantorUniversity of North Texas Health Science Center at Fort Worth
thesis.degree.nameMaster of Science

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