Treatment of Infection in High Risk Patients After Total Knee Arthroplasty by Debridement with Prosthesis Retention: Is Oral Suppressive Therapy the Better Option?

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dc.contributor.advisorSuzuki, Sumihiro
dc.creatorMcBroom, Mandy M.
dc.date.accessioned2019-08-22T21:37:17Z
dc.date.available2019-08-22T21:37:17Z
dc.date.issued2009-05-01
dc.date.submitted2010-06-04T14:06:24-07:00
dc.description.abstractTreatment outcomes of 28 high risk TKA PJI patients treated with either debridement, six weeks I.V. antimicrobial therapy and prosthesis retention, or same treatment with oral chronic suppressive therapy, to ascertain the effectiveness of oral chronic suppressive therapy were retrospectively reviewed in this study. The 2-year cumulative probability of failure for oral suppressive therapy was 7% (95%CI: 0.04 to 27.5) compared to 42% (95%CI: 17.7 to 66.07) for the control group. Oral suppressive therapy was significantly different than control (P= 0.033). This study underscores the importance of combining oral suppressive therapy in select patients with débridement and six weeks I.V. antimicrobial therapy.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12503/29465
dc.language.isoen
dc.provenance.legacyDownloads2061
dc.subjectprosthetic joint infection
dc.subjectoral suppression
dc.subjecttotal knee arthroplasty
dc.titleTreatment of Infection in High Risk Patients After Total Knee Arthroplasty by Debridement with Prosthesis Retention: Is Oral Suppressive Therapy the Better Option?
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentSchool of Public Health
thesis.degree.grantorUniversity of North Texas Health Science Center at Fort Worth
thesis.degree.nameMaster of Public Health

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