Interleukin-6 and its Relationship to Coronary Artery Calcium Burden-North Texas Healthy Heart Study

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dc.contributor.advisorRoberto Cardarelli
dc.contributor.committeeMemberSejong Bae
dc.contributor.committeeMemberRichard Virgilio
dc.creatorAbdulRahim, Nashila
dc.date.accessioned2019-08-22T21:19:04Z
dc.date.available2019-08-22T21:19:04Z
dc.date.issued2008-05-01
dc.date.submitted2013-11-18T12:54:15-08:00
dc.description.abstractAbdulRahim, Nashila, Interleukin-6 and its Relationship to Coronary Artery Calcium Burden- North Texas Healthy Heart Study. Master of Science (Primary Care Clinical Research), May, 2008, pp., 7 tables, 5 figures, bibliography, 73 titles. Atherosclerosis is highly associated with increased serum inflammatory markers. Coronary artery calcium (CAC) burden has allowed researchers to have a non-invasive proxy measure of atherosclerosis. We hypothesized that interleukin-6 (IL-6), after controlling for CV risk factors, would be associated with CAC scores, and this association will be modified by race/ethnicity. 344 subjects were recruited. IL-6 concentrations were measured, and computed tomography was used to calculate CAC scores. After accounting for age, gender, race, smoking, hypertension, diabetes, and cholesterol, a one-unit increase in IL-6 concentration is associated with 1.03 greater odds of an abnormal calcium score (OR: 1.03, 95% CI: 0.98, 1.07). Race/ethnicity did not modify this association. IL-6 did not prove to be a simple clinical marker of CAC.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12503/29240
dc.language.isoen
dc.provenance.legacyDownloads1
dc.subjectBiological Factors
dc.subjectCardiovascular System
dc.subjectMedicine and Health Sciences
dc.subjectInterleukin-6
dc.subjectcoronary artery calcium
dc.subjectatherosclerosis
dc.subjectCV risk factors
dc.subjectabnormal calcium score
dc.subjectbiological factors
dc.subjectsmoking
dc.subjecthypertension
dc.subjectdiabetes
dc.subjectcholesterol
dc.subjectNorth Texas
dc.titleInterleukin-6 and its Relationship to Coronary Artery Calcium Burden-North Texas Healthy Heart Study
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentGraduate School of Biomedical Sciences
thesis.degree.disciplinePrimary Care Clinical Research
thesis.degree.grantorUniversity of North Texas Health Science Center at Fort Worth
thesis.degree.nameMaster of Science

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