Aging-related limit of exercise efficacy on motor decline

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dc.creatorArnold, Jennifer C.
dc.creatorCantu, Mark A.
dc.creatorKasanga, Ella A.
dc.creatorNejtek, Vicki A.
dc.creatorPapa, Evan V.
dc.creatorBugnariu, Nicoleta
dc.creatorSalvatore, Michael F.
dc.creator.orcid0000-0001-6935-1739 (Nejtek, Vicki A.)
dc.date.accessioned2022-11-21T22:08:58Z
dc.date.available2022-11-21T22:08:58Z
dc.date.issued2017-11-27
dc.description.abstractIdentifying lifestyle strategies and allied neurobiological mechanisms that reduce aging-related motor impairment is imperative, given the accelerating number of retirees and increased life expectancy. A physically active lifestyle prior to old age can reduce risk of debilitating motor decline. However, if exercise is initiated after motor decline has begun in the lifespan, it is unknown if aging itself may impose a limit on exercise efficacy to decelerate further aging-related motor decline. In Brown-Norway/Fischer 344 F1 hybrid (BNF) rats, locomotor activity begins to decrease in middle age (12-18 months). One mechanism of aging-related motor decline may be decreased expression of GDNF family receptor, GFRalpha-1, which is decreased in substantia nigra (SN) between 12 and 30 months old. Moderate exercise, beginning at 18 months old, increases nigral GFRalpha-1 and tyrosine hydroxylase (TH) expression within 2 months. In aged rats, replenishing aging-related loss of GFRalpha-1 in SN increases TH in SN alone and locomotor activity. A moderate exercise regimen was initiated in sedentary male BNF rats in a longitudinal study to evaluate if exercise could attenuate aging-related motor decline when initiated at two different ages in the latter half of the lifespan (18 or 24 months old). Motor decline was reversed in the 18-, but not 24-month-old, cohort. However, exercise efficacy in the 18-month-old group was reduced as the rats reached 27 months old. GFRalpha-1 expression was not increased in either cohort. These studies suggest exercise can decelerate motor decline when begun in the latter half of the lifespan, but its efficacy may be limited by age of initiation. Decreased plasticity of GFRalpha-1 expression following exercise may limit its efficacy to reverse motor decline.
dc.description.sponsorshipThis study was fully funded by a grant award (AG040261) by the National Institute on Aging to MF Salvatore. The funder had no role in the study design, data collection and analysis, decision to publish, or manuscript preparation.
dc.identifier.citationArnold, J. C., Cantu, M. A., Kasanga, E. A., Nejtek, V. A., Papa, E. V., Bugnariu, N., & Salvatore, M. F. (2017). Aging-related limit of exercise efficacy on motor decline. PloS one, 12(11), e0188538. https://doi.org/10.1371/journal.pone.0188538
dc.identifier.issn1932-6203
dc.identifier.issue11
dc.identifier.urihttps://hdl.handle.net/20.500.12503/31962
dc.identifier.volume12
dc.publisherPLOS
dc.relation.urihttps://doi.org/10.1371/journal.pone.0188538
dc.rights.holder© 2017 Arnold et al.
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourcePLoS One
dc.subject.meshAging / physiology
dc.subject.meshAnimals
dc.subject.meshBody Weight
dc.subject.meshDopamine / metabolism
dc.subject.meshGlial Cell Line-Derived Neurotrophic Factor Receptors / metabolism
dc.subject.meshMale
dc.subject.meshMotor Activity
dc.subject.meshPhysical Conditioning, Animal
dc.subject.meshRats
dc.subject.meshRats, Inbred F344
dc.subject.meshSubstantia Nigra / enzymology
dc.subject.meshSubstantia Nigra / metabolism
dc.subject.meshTyrosine 3-Monooxygenase / metabolism
dc.titleAging-related limit of exercise efficacy on motor decline
dc.typeArticle
dc.type.materialtext

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