Recent Progress in Vascular Aging: Mechanisms and Its Role in Age-related Diseases

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dc.creatorXu, Xianglai
dc.creatorWang, Brian
dc.creatorRen, Changhong
dc.creatorHu, Jiangnan
dc.creatorGreenberg, David A.
dc.creatorChen, Tianxiang
dc.creatorXie, Liping
dc.creatorJin, Kunlin
dc.creator.orcid0000-0002-1336-348X (Jin, Kunlin)
dc.date.accessioned2022-09-09T14:08:43Z
dc.date.available2022-09-09T14:08:43Z
dc.date.issued2017-07-21
dc.description.abstractAs with many age-related diseases including vascular dysfunction, age is considered an independent and crucial risk factor. Complicated alterations of structure and function in the vasculature are linked with aging hence, understanding the underlying mechanisms of age-induced vascular pathophysiological changes holds possibilities for developing clinical diagnostic methods and new therapeutic strategies. Here, we discuss the underlying molecular mediators that could be involved in vascular aging, e.g., the renin-angiotensin system and pro-inflammatory factors, metalloproteinases, calpain-1, monocyte chemoattractant protein-1 (MCP-1) and TGFbeta-1 as well as the potential roles of testosterone and estrogen. We then relate all of these to clinical manifestations such as vascular dementia and stroke in addition to reviewing the existing clinical measurements and potential interventions for age-related vascular dysfunction.
dc.description.sponsorshipThis work was supported by the China Scholarship Council (No. 201406320118) (to XX), American Heart Association Predoctoral Fellowship (15PRE25700416) (to BW), Sigma Xi Grants-in-Aid of Research (G201503151162287) (to BW), National Natural Science Foundation of China (81301996) (to TC), Ph.D. Programs Foundation of Ministry of Education of China (20130101120017) (to TC). National Institutes of Health grant NS084148-01A1 (to KJ), the National Science Foundation of Beijing (No. 7161014) (to KJ).
dc.identifier.citationXu, X., Wang, B., Ren, C., Hu, J., Greenberg, D. A., Chen, T., Xie, L., & Jin, K. (2017). Recent Progress in Vascular Aging: Mechanisms and Its Role in Age-related Diseases. Aging and disease, 8(4), 486-505. https://doi.org/10.14336/AD.2017.0507
dc.identifier.issn2152-5250
dc.identifier.issue4
dc.identifier.urihttps://hdl.handle.net/20.500.12503/31711
dc.identifier.volume8
dc.publisherJKL International
dc.relation.urihttps://doi.org/10.14336/AD.2017.0507
dc.rights.holder© 2017.
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceAging and Disease
dc.subjectarterial stiffness
dc.subjectdementia
dc.subjectendothelial dysfunction
dc.subjectstroke
dc.subjectvascular aging
dc.titleRecent Progress in Vascular Aging: Mechanisms and Its Role in Age-related Diseases
dc.typeArticle
dc.type.materialtext

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