Molecular Basis for 2B4-CD48 Interactions

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dc.contributor.advisorMathew, Porunelloor A.
dc.contributor.committeeMemberGoldfarb, Ronald
dc.contributor.committeeMemberDas, Hriday
dc.creatorHuynh, Van T.
dc.date.accessioned2019-08-22T21:36:00Z
dc.date.available2019-08-22T21:36:00Z
dc.date.issued2001-08-01
dc.date.submitted2014-02-11T06:49:11-08:00
dc.description.abstractHuynh, Van T., Molecular Basis for 2B4-CD48 Interactions. Master of Science, Molecular Biology and Immunology, August 2001, 93 pp., 3 tables, 19 illustrations, bibliography, 51 titles. Natural killer cells are lymphocytes that play a role against cancer and viral infections. 2B4 is a membrane glycoprotein expressed on natural killer cells. In the present study we characterized 2B4 from mice strains BALB/c, 129/svj and A.CA. Nucleotide and peptide analysis revealed that polymorphyic residues in 2B4 are located in the variable domain. My second project was to determine the amino acids involved in the binding between 2B4 and CD48. Twelve mutations were made in human 2B4 to disrupt their interaction. In the last part of the study, an attempt has been made to elucidate the role of tyrosine and threonine amino acids found in the novel tyrosine motifs (TxYxxI/V) that reside in the cytoplasmic domain.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12503/29450
dc.language.isoen
dc.provenance.legacyDownloads0
dc.subjectCancer Biology
dc.subjectCell and Developmental Biology
dc.subjectCell Biology
dc.subjectCells
dc.subjectCellular and Molecular Physiology
dc.subjectHemic and Immune Systems
dc.subjectImmunity
dc.subjectImmunology and Infectious Disease
dc.subjectLife Sciences
dc.subjectMedical Cell Biology
dc.subjectMedical Immunology
dc.subjectMedical Molecular Biology
dc.subjectMedicine and Health Sciences
dc.subjectMolecular Biology
dc.subjectOther Cell and Developmental Biology
dc.subjectMolecular basis
dc.subject2B4-CD48 interactions
dc.subjectmolecular biology
dc.subjectimmunology
dc.subjectnatural killer cells
dc.subject2B4
dc.subjectmice
dc.subjectamino acids
dc.subjectbinding
dc.subjectCD48
dc.subjectmutations
dc.subjecthuman
dc.subjecttyrosine
dc.subjectthreonine
dc.subjecttyrosine motifs
dc.subjectTxYxxl/V
dc.subjectcytoplasmic domain
dc.titleMolecular Basis for 2B4-CD48 Interactions
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentGraduate School of Biomedical Sciences
thesis.degree.disciplineMicrobiology and Immunology
thesis.degree.grantorUniversity of North Texas Health Science Center at Fort Worth
thesis.degree.nameMaster of Science

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