EGCG and Its Role in Prostate Cancer Angiogenesis

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dc.contributor.advisorPorunelloor Mathew
dc.contributor.committeeMemberMing-Chi Wu
dc.contributor.committeeMemberDan Dimitrijevich
dc.creatorThomas, Rusha
dc.date.accessioned2019-08-22T20:10:41Z
dc.date.available2019-08-22T20:10:41Z
dc.date.issued2005-05-01
dc.date.submitted2014-04-03T09:42:06-07:00
dc.description.abstractThomas, Rusha, EGCG and its role in prostate cancer angiogenesis. Master of Science (Biochemistry and Molecular Biology), May 2005, 47 pages, 14 illustrations, reference list, 44 titles. Hypoxia inducible factor-1 (HIF-1)-mediated upregulation of vascular endothelial growth factor (VEGF) has been implicated in angiogenesis associated with malignancies. HIF-1 consists of a constitutively expressed HIF-1β subunit, and a hypoxia-inducible HIF-1α subunit. Hypoxic induction of HIF-1α correlates with increased transcriptional activation of its downstream target genes, including VEGF. Epidemiologic and laboratory studies indicate that green tea has cancer preventive activity which has been attributed to its polyphenol components, the major one being epigallocatechin gallate (EGCG). This study investigated the effect of EGCG on normoxic VEGF expression in PC-3ML human prostate cancer cells. In contrast to previous studies where EGCG inhibited VEGF expression in breast and colon cancer cell lines, our results demonstrated that EGCG has the ability to upregulate HIF-1α transcription factor via inhibition of prolyl hydroxylation and subsequent von Hippel-Lindau protein interaction. HIF-1α upregulation by EGCG led to increased VEGF promoter activity and protein expression.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12503/27981
dc.language.isoen
dc.provenance.legacyDownloads0
dc.subjectAlternative and Complementary Medicine
dc.subjectBiochemistry
dc.subjectCancer Biology
dc.subjectCell Anatomy
dc.subjectCell and Developmental Biology
dc.subjectCell Biology
dc.subjectCells
dc.subjectChemicals and Drugs
dc.subjectCommunity Health and Preventive Medicine
dc.subjectDevelopmental Biology
dc.subjectDiseases
dc.subjectLife Sciences
dc.subjectMedical Cell Biology
dc.subjectMedical Nutrition
dc.subjectMedical Toxicology
dc.subjectMedicine and Health Sciences
dc.subjectMolecular Biology
dc.subjectNutritional Epidemiology
dc.subjectOncology
dc.subjectOrganic Chemicals
dc.subjectOther Cell and Developmental Biology
dc.subjectToxicology
dc.subjectEGCG
dc.subjectprostate cancer
dc.subjectangiogenesis
dc.subjectHIF-1
dc.subjecthypoxia inducible factor-1
dc.subjectupregulation
dc.subjectvascular endothelial growth factor
dc.subjectVEGF
dc.subjectHIF-1β
dc.subjectHIF-1α
dc.subjecttranscriptional activation
dc.subjecttarget genes
dc.subjectgreen tea
dc.subjectpolyphenol
dc.subjectepigallocatechin gallate
dc.subjectcolon cancer
dc.subjectbreast cancer
dc.titleEGCG and Its Role in Prostate Cancer Angiogenesis
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentGraduate School of Biomedical Sciences
thesis.degree.disciplineBiochemistry and Molecular Biology
thesis.degree.grantorUniversity of North Texas Health Science Center at Fort Worth
thesis.degree.nameMaster of Science

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