Study of 5-HTTLPR and rs25531 to Identify Allele Variants of Offenders Charged with Driving while Intoxicated and Driving under the Influence

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dc.contributor.advisorRhonda Roby
dc.creatorGudep, Ravali
dc.date.accessioned2019-08-22T20:16:44Z
dc.date.available2019-08-22T20:16:44Z
dc.date.issued2013-07-01
dc.date.submitted2013-08-02T13:35:09-07:00
dc.description.abstractSerotonin, also referred to as 5-hydroxytryptamine, is a neurotransmitter which plays a critical role in behavioral and genetics studies. The 5-hydroxytryptamine-transporter-linked polymorphic region (5-HTTLPR), present in the promoter region of the serotonin transporter gene, can have varying number of repeats. In addition, a single nucleotide polymorphism (SNP), rs25531, is present within the repeats. A novel assay was designed to genotype 5-HTTLPR and its SNP variant in a single capillary electrophoretic injection. A total of 1 00 samples received from the Center for Alcohol and Drug Studies at San Diego State University Research Foundation were successfully genotyped.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12503/28158
dc.language.isoen
dc.provenance.legacyDownloads3406
dc.subjectGenetic Phenomena
dc.subjectGenetic Structures
dc.subjectMedical Genetics
dc.subjectMedical Sciences
dc.subjectMedicine and Health Sciences
dc.subject5-HTTLPR
dc.subjectSNP
dc.subjectRS25531
dc.subjectSerotonin transporter gene
dc.subjectGC-Rich
dc.titleStudy of 5-HTTLPR and rs25531 to Identify Allele Variants of Offenders Charged with Driving while Intoxicated and Driving under the Influence
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentGraduate School of Biomedical Sciences
thesis.degree.disciplineForensic Genetics
thesis.degree.grantorUniversity of North Texas Health Science Center at Fort Worth
thesis.degree.nameMaster of Science

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