Discriminative and Negative Reinforcing Properties of the Periaqueductal Gray and the Medial Hypothalamus

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dc.contributor.advisorEmmett-Oglesby, Michael W.
dc.contributor.committeeMemberYorio, Thomas
dc.creatorJung, Marianna E.
dc.date.accessioned2019-08-22T21:41:35Z
dc.date.available2019-08-22T21:41:35Z
dc.date.issued1994-12-01
dc.date.submitted2014-02-24T07:00:05-08:00
dc.description.abstractMarianna Eunsun, Jung, Discriminative and Negative Reinforcing Properties of Electrical brain stimulation of the Periaqueductal Gray and the Medial Hypothalamus. Master of Science [Biomedical Sciences, (Pharmacology)], December, 1994, 123 pp., 24 figures, references, 137 titles. Electrical brain stimulation (EBS) of the periaqueductal gray (PAG) and the medial hypothalamus (MH) is known to serve as a discriminative and a negative reinforcing stimulus (NRS). Using a two-lever food reinforced discrimination paradigm and a switch-off paradigm, the present study investigated the effects of anxiolytic drugs and an anxiogenic drug on these stimulus effects. A prototypic anxiogenic, pentylenetetrazole (PTZ) potentiated both discriminative stimulus and NRS effects, whereas the full benzodiazepine (BZD) agonist diazepam (DZP), the partial BZD agonist abecarnil (ABC) and 5-HT1A agonist buspirone (BUS, chronic regimen) attenuated a NRS effect. A BZD antagonist, flumazenil (FLU) blocked the effects of DZP and ABC on the NRS effects. DZP failed to attenuate the discriminative stimulus effect. Thus, present study extended the use of a switch-off paradigm to detect novel anxiolytic ABC (putative) and BUX as well as an anxiogenic PTZ. In addition, under the condition used in this study, the use of NRS in a switch-off paradigm more reliably detected both anxiolytic drugs and an anxiogenic drug than the use of discriminative stimulus in a two-lever food reinforced paradigm.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12503/29516
dc.language.isoen
dc.provenance.legacyDownloads0
dc.subjectBehavioral Neurobiology
dc.subjectBehavior and Behavior Mechanisms
dc.subjectChemical Actions and Uses
dc.subjectChemicals and Drugs
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.subjectMental and Social Health
dc.subjectNeuroscience and Neurobiology
dc.subjectOther Mental and Social Health
dc.subjectOther Psychiatry and Psychology
dc.subjectPsychiatry and Psychology
dc.subjectDiscriminative
dc.subjectnegative
dc.subjectelectrical brain stimulation
dc.subjectperiaqueductal gray
dc.subjectmedial hypothalamus
dc.subjectEBS
dc.subjectPAG
dc.subjectMH
dc.subjectnegative reinforcing stimulus
dc.subjectNRS
dc.subjectpentylenetetrazole
dc.subjectPTZ
dc.subjectbenzodiazepine
dc.subjectBDZ
dc.subjectdiazepam
dc.subjectDZP
dc.subjecttwo-lever food reinforced discrimination paradigm
dc.subjectanxiolytic drugs
dc.subjectanxiogenic drugs
dc.subjectstimulus effects
dc.titleDiscriminative and Negative Reinforcing Properties of the Periaqueductal Gray and the Medial Hypothalamus
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentGraduate School of Biomedical Sciences
thesis.degree.disciplinePharmacology and Neuroscience
thesis.degree.grantorUniversity of North Texas Health Science Center at Fort Worth
thesis.degree.nameMaster of Science

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