Ubydul Haque, Ph.D.
Permanent URI for this communityhttps://hdl.handle.net/20.500.12503/31219
Assistant Professor, Biostatistics & Epidemiology
Email: Mdubydul.Haque@unthsc.edu
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Browsing Ubydul Haque, Ph.D. by Author "Angulo-Molina, Aracely"
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Item Acute Inflammatory Mediators in Young Adult Patients with COVID-19 in Mexico(MDPI, 2021-08-20) Maldonado-Cabrera, Anahi; Angulo-Molina, Aracely; Haque, Ubydul; Velazquez, Carlos; Alvarez-Villasenor, Andrea S.; Santacruz-Gomez, Karla J.; Gallego-Hernandez, Ana L.Young adults (18-40 years old) are an active population with high risk of infection and transmission of COVID-19. They are considered a low-risk population due to its low 1.0% case fatality rate (CFR). Despite their high clinical usefulness to prevent fatal cases, inflammatory and coagulation biomarkers studies are limited. For this reason, we performed a retrospective cohort study with COVID-19 patients in Hermosillo, Mexico, to assess inflammation, coagulopathy profile, and severity outcomes in young adults. We analyzed blood samples to determine the neutrophil/lymphocyte ratio (NLR), neutrophil/monocyte ratio (NMR), lymphocyte/monocyte ratio (LMR), platelet/lymphocyte ratio (PLR), and C-reactive protein (C-RP). We included epidemiological features and comorbidities, and compared them to the severity status. Only 359 COVID-19-confirmed young adults were included in the ambulatory (44.8%), hospitalized (42.9%), and death (12%) severity groups. Laboratory results showed an increase in NMR, LMR, and C-RP associated with the aggravated patients. Additionally, obesity, arterial hypertension, and type-2 diabetes mellitus (T2DM) were associated with the COVID-19 severity outcome. We found that 9.1% and 30.3% of young adults presented the novel COVID-19-associated coagulopathy (CAC) and the risk of CAC, respectively. These parameters can be considered independent biomarkers reflecting an enhanced inflammatory process related to the COVID-19 prognosis.Item Clinical Symptoms of Arboviruses in Mexico(MDPI, 2020-11-19) Ananth, Sushmitha; Shrestha, Nistha; Treviño C., Jesús A.; Nguyen, Uyen-Sa; Haque, Ubydul; Angulo-Molina, Aracely; Lopez-Lemus, Uriel A.; Lubinda, Jailos; Sharif, Rashed Md; Zaki, Rafdzah Ahmad; Sánchez Casas, Rosa María; Cervantes, Diana; Nandy, RajeshArboviruses such as Chikungunya (CHIKV), Dengue (DENV), and Zika virus (ZIKV) have emerged as a significant public health concern in Mexico. The existing literature lacks evidence regarding the dispersion of arboviruses, thereby limiting public health policy's ability to integrate the diagnosis, management, and prevention. This study seeks to reveal the clinical symptoms of CHIK, DENV, and ZIKV by age group, region, sex, and time across Mexico. The confirmed cases of CHIKV, DENV, and ZIKV were compiled from January 2012 to March 2020. Demographic characteristics analyzed significant clinical symptoms of confirmed cases. Multinomial logistic regression was used to assess the association between clinical symptoms and geographical regions. Females and individuals aged 15 and older had higher rates of reported significant symptoms across all three arboviruses. DENV showed a temporal variation of symptoms by regions 3 and 5, whereas ZIKV presented temporal variables in regions 2 and 4. This study revealed unique and overlapping symptoms between CHIKV, DENV, and ZIKV. However, the differentiation of CHIKV, DENV, and ZIKV is difficult, and diagnostic facilities are not available in rural areas. There is a need for adequately trained healthcare staff alongside well-equipped lab facilities, including hematological tests and imaging facilities.Item Determining Perceived Self-Efficacy for Preventing Dengue Fever in Two Climatically Diverse Mexican States: A Cross-Sectional Study(MDPI, 2022-03-28) Annan, Esther; Angulo-Molina, Aracely; Yaacob, Wan Fairos Wan; Kline, Nolan; Lopez-Lemus, Uriel A.; Haque, UbydulKnowledge of dengue fever and perceived self-efficacy toward dengue prevention does not necessarily translate to the uptake of mosquito control measures. Understanding how these factors (knowledge and self-efficacy) influence mosquito control measures in Mexico is limited. Our study sought to bridge this knowledge gap by assessing individual-level variables that affect the use of mosquito control measures. A cross-sectional survey with 623 participants was administered online in Mexico from April to July 2021. Multiple linear regression and multiple logistic regression models were used to explore factors that predicted mosquito control scale and odds of taking measures to control mosquitoes in the previous year, respectively. Self-efficacy (beta = 0.323, p-value = < 0.0001) and knowledge about dengue reduction scale (beta = 0.316, p-value =< 0.0001) were the most important predictors of mosquito control scale. The linear regression model explained 24.9% of the mosquito control scale variance. Increasing age (OR = 1.064, p-value =< 0.0001) and self-efficacy (OR = 1.020, p-value = 0.0024) were both associated with an increase in the odds of taking measures against mosquitoes in the previous year. There is a potential to increase mosquito control awareness and practices through the increase in knowledge about mosquito reduction and self-efficacy in Mexico.Item Environmental suitability for Aedes aegypti and Aedes albopictus and the spatial distribution of major arboviral infections in Mexico(Elsevier Ltd., 2019-08-12) Lubinda, Jailos; Trevino, C. Jesus A.; Walsh, Mallory Rose; Moore, Adrian J.; Hanafi-Bojd, Ahmad Ali; Akgun, Seval; Zhao, Bingxin; Barro, Alassane S.; Begum, Mst Marium; Jamal, Hera; Angulo-Molina, Aracely; Haque, UbydulBACKGROUND: This paper discusses a comparative geographic distribution of Aedes aegypti and Aedes albopictus mosquitoes in Mexico, using environmental suitability modeling and reported cases of arboviral infections. METHODS: Using presence-only records, we modeled mosquito niches to show how much they influenced the distribution of Ae. aegypti and Ae. albopictus based on mosquito records collected at the municipality level. Mosquito surveillance data were used to create models regarding the predicted suitability of Ae. albopictus and Ae. aegypti mosquitos in Mexico. RESULTS: Ae. albopictus had relatively a better predictive performance (area under the curve, AUC=0.87) to selected bioclimatic variables compared to Ae. aegypti (AUC=0.81). Ae. aegypti were more suitable for areas with minimum temperature of coldest month (Bio6, permutation importance 28.7%) -6 degrees C to 21.5 degrees C, cumulative winter growing degree days (GDD) between 40 and 500, and precipitation of wettest month (Bio13) >8.4mm. Minimum temperature range of the coldest month (Bio6) was -6.6 degrees C to 20.5 degrees C, and average precipitation of the wettest month (Bio13) 8.9mm~600mm were more suitable for the existence of Ae. albopictus. However, arboviral infections maps prepared from the 2012-2016 surveillance data showed cases were reported far beyond predicted municipalities. CONCLUSIONS: This study identified the urgent necessity to start surveillance in 925 additional municipalities that reported arbovirus infections but did not report Aedes mosquito.