Browsing by Subject "Eye Diseases / metabolism"
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Item Involvement of Nrf2 in Ocular Diseases(Hindawi, 2017-03-27) Batliwala, Shehzad; Xavier, Christy; Liu, Yang; Wu, Hongli; Pang, Iok-HouThe human body harbors within it an intricate and delicate balance between oxidants and antioxidants. Any disruption in this checks-and-balances system can lead to harmful consequences in various organs and tissues, such as the eye. This review focuses on the effects of oxidative stress and the role of a particular antioxidant system-the Keap1-Nrf2-ARE pathway-on ocular diseases, specifically age-related macular degeneration, cataracts, diabetic retinopathy, and glaucoma. Together, they are the major causes of blindness in the world.