Browsing by Subject "Surgical Procedures, Operative"
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Item Advanced Problem Solving in the Biotherapeutics Industry: Parameters influencing the delivery of a novel cell therapy product and exploration of a new method for determining activity of Clostridium histolyticum collagenase, a wound debridement enzyme(2015-05-01) Harris, Melanie A.; Jerry W. Simecka; Patricia A. GwirtzBiotechnology is a multi-faceted industry with many unique challenges that require knowledge in a broad range of topics. When working in the wound care field it is necessary to not only create a product in the laboratory, but also effectively bring it to the patient. This task requires many skilled people who can test it for efficacy, design and conduct clinical trials, confirm quality and consistency, design packaging, consider transportation issues and so on. The following investigation focuses on the testing of a cellular product and its accompanying device under various conditions as well as the exploration of a new assay capable of the activity of a wound debridement enzyme. The results of the product/device testing have generally confirmed the comparability of the cellular product devices as well as their resistance to various temperatures encountered in the clinical environment. A new modified assay for the testing of collagenase has been established as precise and comparable to current methods, though it requires more testing to confirm robustness.Item An American Text-Book of Gynecology, Medical and Surgical for Practitioners and Students(W.B. Saunders, 1899-01-01) Baldy, J.M.; Cragin, Edwin M.D.; Etheridge, J.H. M.D.; Goodell, William M.D.; Kelly, Howard M.D.; Krug, Florian M.D.; Montgomery, E.E. M.D.; Pryor, William M.D.; Tuttle, George M.D.; Byford, Henry M.D.2nd Edition. 1899Item Comparative assessment of IV acetaminophen and conscious sedation for pain relief during invasive cardiac procedures(2016-05-01) Alam, Zainab I.; Jerry W. Simecka; Patricia A. Gwirtz; Ranajit ChakrabortyAlthough current consensus in the field of Interventional Cardiology allows for pain medications to be administered at the discretion of the operator, oftentimes, the standard is a cocktail of a benzodiazepine and a narcotic to achieve conscious sedation. Such medications often lead to less than ideal outcomes with longer times to ambulation, delayed discharge and in many cases, drug addiction. This practicum study evaluates the effects of IV acetaminophen (Tylenol) on breakthrough pain during invasive heart procedures in order to replace the current standard of moderate sedation. The results indicate that not only is IV Tylenol as effective as midazolam and fentanyl combined, but it causes a significant decrease in pain response as well.Item Synergy 2008: Annual Research Report(2008-01-01)