Browsing by Subject "postmenopausal women"
Now showing 1 - 3 of 3
- Results Per Page
- Sort Options
Item An Analysis of Osteoporosis-Related Hip Fractures, Using Hospital Discharge Data(2001-12-01) Rubin, Bernard; Antonio A. Rene; Douglas Mains; Muriel MarshallThe purpose of this study is to assess whether a current physician practice may inadequately diagnose osteoporosis in a high risk population of postmenopausal women who have sustained a hip fracture. A review of all patients discharged from Texas hospitals during calendar year 1999 was analyzed, using the Public Use Data File provided through the Texas Health Care Information Council. A total of 13,628 women over the age of 55 were admitted to hospital with a fractured hip. Only 2,233, or 16.3%, of women were also coded with the diagnosis of osteoporosis (P [less than] 0.001). Forty to fifty percent of postmenopausal women have osteoporosis. Therefore, women presenting with a fragility fracture form an even more at-risk subset of the population, such that one would expect a majority of these women to carry a diagnosis of osteoporosis. Percentages of Caucasian, non-Hispanic women in each group were comparable. The age distribution in each group was comparable, implying that the coded diagnosis of osteoporosis was not related to the age of the women when admitted to the hospital. In conclusion, physicians practicing in Texas during calendar year 1999 inadequately diagnosed osteoporosis in a high risk population of postmenopausal women who were admitted to hospital with fractured hip. Future analysis of subsequent analysis databases will be able to identify whether or not continuing medical education efforts will cause physicians to diagnose osteoporosis in this high risk population more frequently.Item Hormone Replacement Therapy: Investigating Language Barriers(2002-04-26) Gamber, Mark A.; Muriel Marshall; Gilbert Ramirez; Janice KneblHormone Replacement Therapy: Investigating Language Barriers. Mark Gamber, BA, BS; Muriel Marhsall, DO, DrPH; Gilbert Ramirez, DrPH, Janice Knebl, DO; Karen Godwin, PhD; Hector Balzacar, PhD; Craig Whiting, DO. Objective: To investigate the relationship between the language spoken (Spanish or English) by the Hispanic patient when talking to their doctor and the patient’s use of HRT. Design: Retrospective chart review. Setting: Northside Family Practice clinic, UNTHSC in Ft. Worth, Texas. 102 postmenopausal Hispanic women. Measurement: HRT use, Spanish or English speaking, natural or surgical menopause. Results: A total of 102 postmenopausal Hispanic females met the inclusion criteria for chart review. The mean age of English speakers is 66.7 years old. The mean age of the Spanish speakers is 64.93 years old. 54% (55) spoke Spanish at their clinic visit and 46% (47) spoke English. Of the 55 Spanish speakers, 36% had at some point used HRT while 64% had never used HRT. Of the 47 English speakers, 49% had at some point used HRT while 51% had never used HRT. There is not a significant difference (p=0.20) when comparing language spoken by the patient at the clinic visit and whether they are prescribed HRT. Conclusion: While a significant difference was not found between the two groups, a greater percentage of English speaker (48%) than Spanish speaking (36%) Hispanic females are prescribed HRT in this study. In fact, when adjusted for age, English speakers were 1.88 times more likely to have used HRT than Spanish speakers. Based on the apparent need to bridge the language barrier between physicians and patients over issues important as menopause and HRT, more research is needed in this area. Key Words: Hormone Replacement Therapy, Hispanic, Women. University of North Texas Health Science Center; Ft. Worth, Texas (MG, MM, GR, JK, KG, HB, CW) Address correspondence and reprint requests to Mark Gamber c/o Dr. Muriel Marshall, University of North Texas Health Science Center; 3500 Camp Bowie Blvd; Fort Worth, Texas 76107. 817-735-2440; 817-735-2137 (fax). mgamber@hotmail.com. Word Count: 1311. Number of Tables: 1. Number of References: 16. Date of Submittal: 4/26/02.Item Modulation of Manganese Superoxide Dismutase by 17-Beta Estradiol(2008-05-01) Gottipati, Srinivas; Thomas YorioGottipati, Srinivas. Modulation of manganese superoxide dismutase activity by 17-beta estradiol. Master of Science (Cell Biology and Genetics), May, 2008. We have previously reported that 17β-Estradiol (17β-E2) can protect human lens epithelial cells against oxidative stress by preserving mitochondrial function, acting as a positive regulator of the MAPK signal transduction pathway. While pERK plays a significant role in stabilizing the inner mitochondrial membrane to maintain the mitochondrial membrane potential during oxidative stress, the protective mechanisms activated by 17β-E2 are probably multifactorial acting via both genomic and non genomic pathways. This study examined the effects of 17β-E2 on the expression and activity of MnSOD, which is present exclusively in the mitochondria, as a possible mechanism by which it affords protection against oxidative stress. Our results demonstrate that 17β-E2 rapidly increases the activity of MnSOD in a time dependent manner. This augmentation of activity of MnSOD by 17β-E2 is seen in the absence of a corresponding increase in the mRNA and protein expression, thereby which estrogens protect the cells against oxidative stress will help us in developing estrogens to be useful therapies for the prevention of cataract in postmenopausal women and non feminizing estrogens may provide similar protection in men.