Browsing by Subject "sleep"
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Item Chronic Disease, sleep quality, and TNF-alpha: Understanding Pathophysiologic Processes(2009-08-01) Sprawls, Kelly S.; Kathryn CardarelliThe purpose of this study was to explore the association between poor sleep quality and TNF-alpha levels and determine which chronic diseases modify this relationship. In this cross-sectional study of 75 participants, we ascertained sleep quality by means of the Pittsburgh Sleep Quality Index (PSQI). Analyses revealed females were more likely to experience poor sleep quality compared to males. Although sleep quality was not associated with TNFlevels, significant associations were detected with dyslipidemia and tobacco use. Interestingly, we discovered hypertension and diabetes modified the relationship, creating a trend toward inverse associations. As for the relationship between chronic disease and sleep quality, depressive symptomatology and pain were strongly correlated. Unexpectedly, diabetes bordered associations with improved sleep quality. Larger longitudinal studies are needed to confirm these relationships and explore the effects of improved sleep quality and chronic disease management on TNF-alpha levels.Item The Association of Multimorbidity With Whole Health Activities Among Adults in the United States: Evidence From the NHIS and BRFSS(Academic Consortium for Integrative Medicine & Health, 2023-05-08) Neba, Rolake A.; Warner, Mayela; Manning, Sydney E.; Wiener, R. Constance; Sambamoorthi, UshaBACKGROUND: Whole health is a holistic approach encompassing integrative medicine, emotional, and spiritual health and is critical to improving health outcomes among individuals with multimorbidity. OBJECTIVE: To examine the prevalence of Whole Health activities and the association of multimorbidity and Whole Health activities using nationally representative datasets. METHODS: As no single dataset has information on Whole Health self-care activities, data from the 2017 National Health Interview Survey (n = 25 134) was used to measure participants' mind-body therapy usage, sleep, mental health, and physical activity. We used the 2017 Behavioral Risk Factor Surveillance System (n = 347 029) to assess regular vegetable and/or fruit consumption. RESULTS: A significantly lower percentage of adults with multimorbidity had adequate sleep (58.2%vs.67.1%), no psychological distress (71.8%vs.82.1%), adequate physical activity (48.2%vs.62.1%), and regular vegetable and/or fruit consumption (54.2%vs.56.6%) compared to those without multimorbidity. Although lower percentages of adults with multimorbidity utilized mind-body therapies (22.9%vs.25.2%), the association was reversed when adjusted for socioeconomic factors. In the fully adjusted models, adults with multimorbidity were more likely to use mind-body therapies (AOR = 1.19, 95%CI = 1.09, 1.31). Furthermore, when adjusting for other independent variables, the associations of multimorbidity with sleep, psychological distress, and diet were exacerbated, and the association of multimorbidity with physical activity was attenuated. CONCLUSION: Adults with multimorbidity were less likely to engage in most of the Whole Health activities except mind-body therapies compared to the no multimorbidity group. Findings suggest that adjustment for other factors such as age and socioeconomic status changed the magnitude and direction of the association of multimorbidity with Whole Health activities.Item The impact of circadian misalignment on health and wellness in medical students(2020-05) Roig, Christopher A.; Roane, Brandy M.; Cunningham, J. Thomas; Gwirtz, Patricia A.Circadian misalignment, or "social jetlag" refers to a mismatch between the internal circadian clock and external timings (e.g. societal timings) and behaviorally manifests as inappropriately timed sleep/wake cycles or misalignment of sleep patterns with meal timings. Previous literature shows circadian misalignment to contribute to a large number of adverse health outcomes including metabolic changes and disorders, mood disturbance, and decreased daytime functioning. A number of the adverse health outcomes of circadian misalignment, such as depression, suicidality, and burnout are all common within the medical student population. Medical students also tend to exhibit behaviors which promote circadian misalignment, such as staying up late to study, pulling all-nighters for exams, and sleeping in on weekends. Despite these links, very little literature exists regarding the prevalence, manifestations, and effects of circadian misalignment on medical students. This study identifies key behaviors related to circadian misalignment in medical students, as well as identifying negative outcomes associated with these behaviors.