Browsing by Subject "systematic review"
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Item Appropriate Delivery Of Care In American Patients With Hepatocellular Carcinoma: A Systematic Review(2013-05-01) Tan, Debra; Lykens, KristineObjective: To assess and provide in-depth analysis of appropriate delivery of care in patients with hepatocellular carcinoma (HCC) based on time of diagnosis within Americans in the United States. Design: Meta-analysis of retrospective cohort studies describing receipt of appropriate treatment utilization and delivery of care for HCC. Results: Among all twenty-three included studies, a total of 7,986 of 17,286 (44.4%, 95% CI 43.7-45.1%) patients received overall treatment. Of 48,200 patients with HCC, only 10,518 (21.8%, 95% CI 21.5-22.2%) patients received curative treatment and 6,810 of 11,776 (57.8%, 95% CI 56.9-58.7%) patients who were within early stage HCC received curative treatment. Conclusion: HCC treatment is underutilized in the United States. Although the pooled treatment rate for early HCC patients receiving curative treatment is somewhat better, only about four-sevenths receive appropriate care. There are significant socio-demographic disparities with the lowest treatment rates in non-Caucasians and non-private insurance patients.Item Safety and Efficacy of Alefacept, Efalizumab, Etanercept, and Infliximab in Treating Moderate to Severe Psoriasis: A Meta-Analysis of Randomized Controlled Trials(2007-05-03) Brimhall, Angela K.; John Licciardone; Roberto Cardarelli; Richard VirgilioBrimhall, Angela K., Master of Science, Clinical Research and Academic Medicine, May 19, 2007, Safety and Efficacy of Alefacept, Efalizumab, Etanercept, and Infliximab in Treating Moderate to Severe Plaque Psoriasis: A Meta-Analysis of Randomized Controlled Trials. Pages=41, Tables=3, Figures=9, Bibliography=61 titles. To evaluate and compare efficacy and safety of biological agents in the treatment of plaque psoriasis, data was identified through four parallel systematic reviews. Randomized, controlled, double-blind, monotherapy trials of alefacept, efalizumab, etanercept and infliximab were selected. Sixteen studies comprising 7,931 patients met inclusion criteria. Efficacy was measured by pooled relative risk (RR) and number needed to treat (NNT) of PASI 75 achievement as compared to placebo. Each biological agent was efficacious (P [less than] .001); however, there was a graded response for achievement of PASI 75. The risk of one or more adverse event was increased in the alefacept, efalizumab, and infliximab groups compared to placebo.Item Social Media Use and Mental Health: A Global Analysis(MDPI, 2022-11-24) Ulvi, Osman; Karamehic-Muratovic, Ajlina; Baghbanzadeh, Mahdi; Bashir, Ateka; Smith, Jacob; Haque, UbydulResearch indicates that excessive use of social media can be related to depression and anxiety. This study conducted a systematic review of social media and mental health, focusing on Facebook, Twitter, and Instagram. Based on inclusion criteria from the systematic review, a meta-analysis was conducted to explore and summarize studies from the empirical literature on the relationship between social media and mental health. Using PRISMA guidelines on PubMed and Google Scholar, a literature search from January 2010 to June 2020 was conducted to identify studies addressing the relationship between social media sites and mental health. Of the 39 studies identified, 20 were included in the meta-analysis. Results indicate that while social media can create a sense of community for the user, excessive and increased use of social media, particularly among those who are vulnerable, is correlated with depression and other mental health disorders.Item The Dose Dependent Effect of Alcohol Consumption on Cardiovascular Disease and Its Risk Facotrs-A Systematic Review(2007-12-01) Bhamidimarri, Kalyan Ram; Karan SinghBhamidimarri, Kalyan R; The Dose Dependent Effect of Alcohol Consumption on Cardiovascular Disease and Its Risk Factors-A Systematic Review. Master of Public Health (Biostatistics), December 2007, 41 pp; 2 tables, 3 illustrations, bibliography, 60 titles. Effects of alcohol on cardiovascular health are varied and conflicting. Moderate alcohol drinking has been shown to reduce the incidence of cardiovascular disease by having a direct influence on vascular and haemostatic factors or indirectly by influencing atherosclerosis, cholesterol and insulin resistance. Studies about effects of alcohol on cardiovascular diseases and its risk factors published through 1995 to 2007 were searched in different databases and those meeting eligibility criteria were analyzed. Thirty one studies were reviewed and data analyzed to verify dose dependent effects of alcohol. Although several factors account for different effects of alcohol, moderate consumption of alcohol amounting to less than one drink or 14 grams per day is protective for cardiovascular disease possibly due to its impact on the risk factors. Randomized controlled studies which can be done in this regard might clearly suggest a dose dependent effect of alcohol on cardiovascular and overall survival.