Publications -- Eul Hyun Suh

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12503/32337

This collection is limited to articles published under the terms of a creative commons license or other open access publishing agreement since 2016. It is not intended as a complete list of the author's works.

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    Competitive Displacement Restores the Hyperpolarized (15)N NMR Signal in Blood Plasma
    (American Chemical Society, 2023-03-28) Suh, Eul H.; Kovacs, Zoltan
    Hyperpolarized (HP) NMR can improve the sensitivity of conventional NMR experiments by several orders of magnitude, thereby making it feasible to detect the signal of low sensitivity nuclei such as (13)C and (15)N nuclei in vivo. Hyperpolarized substrates are usually administered by direct injection into the bloodstream, and interaction with serum albumin can cause rapid decay of the hyperpolarized signal due to the shortening of the spin-lattice (T(1)) relaxation time. Here we report that the (15)N T(1) of (15)N labeled, partially deuterated tris(2-pyridylmethyl)amine decreases dramatically upon binding to albumin to such an extent that no HP-(15) signal could be detected. We also demonstrate that the signal could be restored using a competitive displacer, iophenoxic acid, which binds stronger to albumin than tris(2-pyridylmethyl)amine. The methodology presented here eliminates the undesirable effect of albumin binding and should widen the range of hyperpolarized probes for in vivo studies.