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The impact of medication therapy management on polypharmacy in people living with HIV/AIDS
(2020-08)Polypharmacy, defined as the concurrent use of multiple medications simultaneously, is increasingly common in people living with HIV/AIDS (PLWHA) due to the use of antiretroviral and non-antiretroviral drugs for the treatment ... -
Endothelin-1 mediated decline in mitochondrial function contributes to neurodegeneration in glaucoma
(2020-08)Glaucoma is an optic neuropathy with multifactorial etiologies, commonly associated with elevated intraocular pressure (IOP) and characterized by degeneration of the optic nerve, loss of retinal ganglion cells (RGC), cupping ... -
Chronic testosterone deprivation sensitizes the middle-aged rat brain to damaging effects of testosterone
(2020-05)Levels of the testosterone (T) fall in aging men. Recently, the number of men obtaining testosterone replacement therapy (TRT) has increased dramatically. However, other consequences of aging, such as increased oxidative ... -
The impact of circadian misalignment on health and wellness in medical students
(2020-05)Circadian misalignment, or "social jetlag" refers to a mismatch between the internal circadian clock and external timings (e.g. societal timings) and behaviorally manifests as inappropriately timed sleep/wake cycles or ... -
An anatomical study of the pelvic diaphragm
(2019-08)The pelvic diaphragm represents a group of muscles located at the pelvic outlet and is involved in pelvic floor dysfunctions. Alternative therapies targeting obturator internus have been suggested in strengthening pelvic ... -
Increased resolution screening of the pharmacogenetic gene CYP2D6 with microarray technology
(2019-08)Autopsy is a primary methodology used for assessing cause and/or manner of death in medicolegal investigations. Some autopsies, however, do not resolve the cause of death unambiguously or there is no evident pathology to ... -
Changes in Healthcare Utilization and Charges Among Supportive Housing Residents Enrolled in a Health Coaching Program
(2019-05)The effectiveness of self-management programs on healthcare use outcomes is an active area of research with inconsistent results. This study was the first to evaluate changes in healthcare utilization (including hospital ... -
Illicit Substance Use Among a Sample of Subsidized Housing Residents: Concordance, Longitudinal Trends, and Quality of Life
(2019-05)This three-paper model dissertation investigates issues related to self-reported substance use. Self-report is a less invasive and expensive method of collecting substance use behavior when compared to a toxicological test, ... -
Validation of HemaSpotTM devices for the collection and long-term, room temperature storage of biological fluids from forensic reference samples
(2019-05)As forensic DNA samples spend more time in storage, collection devices capable of long-term, room temperature preservation provide cost-effective solutions. This project evaluated two different HemaSpot(TM) cartridges for ... -
Impact Of Culture Conditions on Primary Astrocyte Phenotype
(2019-05)Although previously thought to be passive support cells in the central nervous system (CNS), recent findings introduced critical contributions of astrocytes to numerous CNS functions like energy metabolism, ion and water ... -
Assessment of Oxford Nanopore Technologies as a Sequencing Platform for Increased Taxonomic Resolution of Microbial Communities
(2019-05)Microbiome profiling for forensic identification is an emerging area of research. Profiling the microbiome of trace evidence for forensic cases will become more prevalent as more reliable, accurate, and efficient methodology ... -
Connexin 43 Contributes to Estrogen Protection against Oxidative Stress in Cortical Astrocytes
(2019-05)Age-related brain disorders are associated with the decline in the ability of brain cells to cope with homeostatic challenge. Although all major brain cell types have the capacity to respond to homeostatic challenges, ... -
Analysis of HemaSpot[TM]-HF and HemaSpot[TM]-HD Sampling Kits Using Trace DNA
(2019-05)Spot On Sciences, Inc. has recently developed a new device, the HemaSpot[TM], which allows for samples to be stored safely at ambient temperatures. The UNTHSC FGEN program was contacted to conduct a research study to ... -
Sequencing Long Amplicon Microsatellite Loci Using the Oxford Nanopore Technologies MinION[TM] Device
(2019-05)Forensic DNA typing utilizes highly variable short tandem repeat (STR) markers to differentiate individuals. Despite the power and reliability of current techniques, sequence-level variations are masked in the length-based ... -
Bioengineered Nanoparticles for Targeted Cancer Therapy
(2018-05)Despite improved overall survival in cancer patients over the past 50 years, limited advances have been made in treating patients with metastatic cancers. Multiple types of cancers demonstrate the unique ability to ... -
Latent Tuberculosis Infection Testing and Treatment in the Private Sector: Evidence from Commercial Health Insurance Claims
(2017-05)Targeted identification and treatment of people with latent tuberculosis infection (LTBI) are key components of the US tuberculosis (TB) elimination strategy. Little research on LTBI testing and treatment has been conducted ... -
Investigating the Complex Relationship Between Adverse Childhood Experiences and Oral Health-Related Quality of Life
(2017-05)Dental caries is one of the most common chronic disease in children and continues to be a significant global public health concern. Evidence indicates that chronic diseases, and adverse childhood experiences (ACEs), have ... -
Phenotype of Neurons in the Nucleus Tractus Solitarius Labeled using an Optogenetic Construct with a CaMKIIa Promoter
(2017-05)Optogenetics is a very useful technique used to activate or inhibit specific cells of interest in specific brain regions. The purpose of this study was to determine the phenotype of cells within the nucleus tractus solitarius ... -
Clinical Significance of Annexin A2 in Predicting Poor Prognosis in African American Women with Triple-Negative Breast Cancer
(2017-05)Triple-negative breast cancers (TNBC) are identified by the absence of these three major receptors that drive most breast cancer subtypes. TNBC is the most aggressive breast cancer subtype and studies have shown that the ... -
Pyruvate-enriched Preservation of Machine Perfused Kidneys
(2020-05)Purpose: Kidney transplantation remains the gold-standard treatment for patients diagnosed with end-stage renal disease (ESRD). However, the demand for donors currently far outpaces the supply. Kidneys donated after cardiac ...
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