In Vitro Effect of CNTF, FGF-9, IL-1α on Human Optic Nerve Head Astrocytes
Abstract
Tovar, Tara., In Vitro Effect of CNTF, FGF-9, and IL-1α on Human Optic Nerve Head Astrocytes. Master of Science (Biomedical Sciences), August 2004, 100 pp., 4 tables, 35 illustrations, bibliography, 163 titles. Glaucoma is a leading cause of blindness worldwide. A major risk factor for glaucoma is increased intraocular pressure that leads to pathological changes in the optic nerve head (ONH). Astrocytes within the ONH become activated in glaucoma and may create an environment detrimental to retinal ganglion cell axons. The factors that cause activation of the ONH astrocytes (ONA) are unknown, although there is evidence that CNTF, FGF-9, and IL-1α activate glial cells within the CNS. The purpose of this research was to determine if exogenous CNTF, FGF-9, and/or IL-1α activate human ONH astrocytes.
Subject
Cell and Developmental Biology
Cell Biology
Cells
Chemicals and Drugs
Eye Diseases
Life Sciences
Medicine and Health Sciences
Ophthalmology
Optometry
Other Cell and Developmental Biology
Vision Science
In vitro
effect
CNTF
FGF-9
IL-1α
human optic nerve head astrocytes
glaucoma
intraocular pressure
optic nerve head
ONH
retinal ganglion cell axons
glial cells
Cell Biology
Cells
Chemicals and Drugs
Eye Diseases
Life Sciences
Medicine and Health Sciences
Ophthalmology
Optometry
Other Cell and Developmental Biology
Vision Science
In vitro
effect
CNTF
FGF-9
IL-1α
human optic nerve head astrocytes
glaucoma
intraocular pressure
optic nerve head
ONH
retinal ganglion cell axons
glial cells