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    ParaDNA: A Novel Instrument for Presumptive DNA Analysis

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    2018_05_gsbs_Moussa_Ola_thesis.pdf (2.861Mb)
    Date
    2018-05
    Author
    Moussa, Ola
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    Abstract
    Current methods for human identification are time consuming and can take weeks to complete, leading to a backlog of evidence needing to be processed and a slowdown in investigations. The ParaDNA[R] Instrument is designed to address this issue using the Screening and Intelligence Systems which can detect the relative amount of DNA in an evidence item, and analyze 5 short tandem repeats (STRs) and Amelogenin, respectively [3]. The Instrument uses HyBeacons[R] which target specific STRs to identify the presence of DNA, and detect STR alleles. This is a validation of the ParaDNA[R] Screening and Intelligence Systems using saliva and blood samples to assess the sensitivity and reliability of the instrument. The data collected using the ParaDNA[R] Instrument show that it can reliably identify the relative amount of DNA in a sample, and display useful STR profiles that are 99% concordant with Qiagen Investigator 24Plex QS STR Kits.
    Subject
    DNA
    Forensics
    Genetics
    ParaDNA
    Forensic Genetics, instrumentation
    Microsatellite Repeats
    Validation Studies
    URI
    https://hdl.handle.net/20.500.12503/29690
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