Long-term intermittent fasting improves neurological function by promoting angiogenesis after cerebral ischemia via growth differentiation factor 11 signaling activation

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dc.creatorLiu, Zhao
dc.creatorLiu, Mengjie
dc.creatorJia, Gongwei
dc.creatorLi, Jiani
dc.creatorNiu, Lingchuan
dc.creatorZhang, Huiji
dc.creatorQi, Yunwen
dc.creatorSun, Houchao
dc.creatorYan, Liang-Jun
dc.creatorMa, Jingxi
dc.creator.orcid0000-0002-5815-5430 (Yan, Liang-Jun)
dc.date.accessioned2023-04-12T20:00:13Z
dc.date.available2023-04-12T20:00:13Z
dc.date.issued2023-03-31
dc.description.abstractIntermittent fasting (IF), an alternative to caloric restriction, is a form of time restricted eating. IF conditioning has been suggested to have neuroprotective effects and potential long-term brain health benefits. But the mechanism underlying remains unclear. The present study focused on the cerebral angiogenesis effect of IF on ischemic rats. Using a rat middle cerebral artery occlusion model, we assessed neurological outcomes and various vascular parameters such as microvessel density (MVD), regional cerebral blood flow (rCBF), proliferation of endothelial cells (ECs), and functional vessels in the peri-infarct area. IF conditioning ameliorated the modified neurological severity score and adhesive removal test, increased MVD, and activated growth differentiation factor 11 (GDF11)/activin-like kinase 5 (ALK5) pathways in a time-dependent manner. In addition, long-term IF conditioning stimulated proliferation of ECs, promoted rCBF, and upregulated the total vessel surface area as well as the number of microvessel branch points through GDF11/ALK5 pathways. These data suggest that long-term IF conditioning improves neurological outcomes after cerebral ischemia, and that this positive effect is mediated partly by angiogenesis in the peri-infarct area and improvement of functional perfusion microvessels in part by activating the GDF11/ALK5 signaling pathway.
dc.description.sponsorshipScience and Technology Planning Project of Yuzhong District of Chongqing (20210161), Chongqing Municipal Health Commission (2020MSXM106, 2021ZY023818, 2018ZDXM022), Natural Science Foundation of Chongqing (cstc2021jcyj-msxmX0071, CSTB2022NSCQ-MSX1457).
dc.identifier.citationLiu, Z., Liu, M., Jia, G., Li, J., Niu, L., Zhang, H., Qi, Y., Sun, H., Yan, L. J., & Ma, J. (2023). Long-term intermittent fasting improves neurological function by promoting angiogenesis after cerebral ischemia via growth differentiation factor 11 signaling activation. PloS one, 18(3), e0282338. https://doi.org/10.1371/journal.pone.0282338
dc.identifier.issn1932-6203
dc.identifier.issue3
dc.identifier.urihttps://hdl.handle.net/20.500.12503/32343
dc.identifier.volume18
dc.publisherPLOS
dc.relation.urihttps://doi.org/10.1371/journal.pone.0282338
dc.rights.holder© 2023 Liu et al.
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourcePLoS One
dc.subject.meshRats
dc.subject.meshAnimals
dc.subject.meshEndothelial Cells / metabolism
dc.subject.meshIntermittent Fasting
dc.subject.meshBrain Ischemia
dc.subject.meshSignal Transduction
dc.subject.meshInfarction, Middle Cerebral Artery
dc.subject.meshGrowth Differentiation Factors / pharmacology
dc.subject.meshDisease Models, Animal
dc.titleLong-term intermittent fasting improves neurological function by promoting angiogenesis after cerebral ischemia via growth differentiation factor 11 signaling activation
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dc.type.materialArticle

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