Nanoparticle Effects on Human Platelets in Vitro: A Comparison between PAMAM and Triazine Dendrimers

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dc.creatorEnciso, Alan E.
dc.creatorNeun, Barry
dc.creatorRodriguez, Jamie
dc.creatorRanjan, Amalendu P.
dc.creatorDobrovolskaia, Marina A.
dc.creatorSimanek, Eric E.
dc.creator.orcid0000-0002-3641-7751 (Ranjan, Amalendu P.)
dc.date.accessioned2022-11-17T21:59:25Z
dc.date.available2022-11-17T21:59:25Z
dc.date.issued2016-03-29
dc.description.abstractTriazine and PAMAM dendrimers of similar size and number of cationic surface groups were compared for their ability to promote platelet aggregation. Triazine dendrimers (G3, G5 and G7) varied in molecular weight from 8 kDa-130 kDa and in surface groups 16-256. PAMAM dendrimers selected for comparison included G3 (7 kDa, 32 surface groups) and G6 (58 kDa, 256 surface groups). The treatment of human platelet-rich plasma (PRP) with low generation triazine dendrimers (0.01-1 microM) did not show any significant effect in human platelet aggregation in vitro; however, the treatment of PRP with larger generations promotes an effective aggregation. These results are in agreement with studies performed with PAMAM dendrimers, where large generations promote aggregation. Triazine dendrimers promote aggregation less aggressively than PAMAM dendrimers, a factor attributed to differences in cationic charge or the formation of supramolecular assemblies of dendrimers.
dc.description.sponsorshipWe thank the Robert A. Welch Foundation (P-0008) and DOD (W81XWH-12-1-0338). The study was supported in part by federal funds from the National Cancer Institute, National Institutes of Health, under contract HHSN261200800001E (M.D., B.N. and J.R.). The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government.
dc.identifier.citationEnciso, A. E., Neun, B., Rodriguez, J., Ranjan, A. P., Dobrovolskaia, M. A., & Simanek, E. E. (2016). Nanoparticle Effects on Human Platelets in Vitro: A Comparison between PAMAM and Triazine Dendrimers. Molecules (Basel, Switzerland), 21(4), 428. https://doi.org/10.3390/molecules21040428
dc.identifier.issn1420-3049
dc.identifier.issue4
dc.identifier.urihttps://hdl.handle.net/20.500.12503/31940
dc.identifier.volume21
dc.publisherMDPI
dc.relation.urihttps://doi.org/10.3390/molecules21040428
dc.rights.holder© 2016 by the authors; licensee MDPI, Basel, Switzerland.
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceMolecules
dc.subjectPAMAM
dc.subjectbiocompatibility
dc.subjectdendrimer
dc.subjectplatelet
dc.subjecttriazine
dc.subject.meshBlood Platelets / drug effects
dc.subject.meshDendrimers / pharmacology
dc.subject.meshHumans
dc.subject.meshNanoparticles / chemistry
dc.subject.meshPlatelet Aggregation / drug effects
dc.subject.meshTriazines / pharmacology
dc.titleNanoparticle Effects on Human Platelets in Vitro: A Comparison between PAMAM and Triazine Dendrimers
dc.typeArticle
dc.type.materialtext

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