Proteomic profiles of prevalent mild cognitive impairment and Alzheimer's disease among adults with Down syndrome

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dc.creatorPetersen, Melissa E.
dc.creatorZhang, Fan
dc.creatorKrinsky-McHale, Sharon J.
dc.creatorSilverman, Wayne
dc.creatorLee, Joseph H.
dc.creatorPang, Deborah
dc.creatorHall, James R.
dc.creatorSchupf, Nicole
dc.creatorO'Bryant, Sid E.
dc.creator.orcid0000-0003-0582-5266 (O'Bryant, Sid E.)
dc.creator.orcid0000-0002-3920-5877 (Petersen, Melissa E.)
dc.date.accessioned2022-07-07T13:54:27Z
dc.date.available2022-07-07T13:54:27Z
dc.date.issued2020-04-17
dc.description.abstractIntroduction: We sought to determine if a proteomic profile approach developed to detect Alzheimer's disease (AD) in the general population would apply to adults with Down syndrome (DS). Methods: Plasma samples were obtained from 398 members of a community-based cohort of adults with DS. A total of n = 186 participants were determined to be non-demented and without mild cognitive impairment (MCI) at baseline and throughout follow-up; n = 50 had prevalent MCI; n = 42 had prevalent AD. Results: The proteomic profile yielded an area under the curve (AUC) of 0.92, sensitivity (SN) = 0.80, and specificity (SP) = 0.98 detecting prevalent MCI. For detecting prevalent AD, the proteomic profile yielded an AUC of 0.89, SN = 0.81, and SP = 0.97. The overall profile closely resembled our previously published profile of AD in the general population. Discussion: These data provide evidence of the applicability of our blood-based algorithm for detecting MCI/AD among adults with DS.
dc.description.sponsorshipThis work was supported by National Institutes of Health grants; P01 HD035897, U54 HD079123, U01 AG051412 and R01 AG014673, by grant IIRG-08-90655 from the Alzheimer's Association as well as by funds from the New York State Office for People with Developmental Disabilities. This work was also supported by the National Institute on Aging by grant R01 AG058537.
dc.identifier.citationPetersen, M., Zhang, F., Krinsky-McHale, S. J., Silverman, W., Lee, J. H., Pang, D., Hall, J., Schupf, N., & O'Bryant, S. E. (2020). Proteomic profiles of prevalent mild cognitive impairment and Alzheimer's disease among adults with Down syndrome. Alzheimer's & dementia (Amsterdam, Netherlands), 12(1), e12023. https://doi.org/10.1002/dad2.12023
dc.identifier.issn2352-8729
dc.identifier.issue1
dc.identifier.urihttps://hdl.handle.net/20.500.12503/31541
dc.identifier.volume12
dc.publisherWiley Periodicals, Inc.
dc.relation.urihttps://doi.org/10.1002/dad2.12023
dc.rights.holderCopyright © 2020 The Authors.
dc.rights.licenseAttribution-NonCommercial 4.0 International (CC BY-NC 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.sourceAlzheimer's & Dementia Diagnosis, Assessment & Disease Monitoring
dc.subjectAlzheimer's disease
dc.subjectblood based
dc.subject.meshAlzheimer Disease
dc.subject.meshDown Syndrome
dc.subject.meshBiomarkers
dc.subject.meshPlasma
dc.titleProteomic profiles of prevalent mild cognitive impairment and Alzheimer's disease among adults with Down syndrome
dc.typeArticle
dc.type.materialtext

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