HIV-1-Mediated Acceleration of Oncovirus-Related Non-AIDS-Defining Cancers

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dc.creatorProulx, Jessica
dc.creatorGhaly, Maria
dc.creatorPark, InWoo
dc.creatorBorgmann, Kathleen
dc.creator.orcid0000-0003-0897-390X (Borgmann, Kathleen)
dc.creator.orcid0000-0002-5452-0461 (Proulx, Jessica)
dc.date.accessioned2022-07-12T16:34:46Z
dc.date.available2022-07-12T16:34:46Z
dc.date.issued2022-03-25
dc.description.abstractWith the advent of combination antiretroviral therapy (cART), overall survival has been improved, and the incidence of acquired immunodeficiency syndrome (AIDS)-defining cancers has also been remarkably reduced. However, non-AIDS-defining cancers among human immunodeficiency virus-1 (HIV-1)-associated malignancies have increased significantly so that cancer is the leading cause of death in people living with HIV in certain highly developed countries, such as France. However, it is currently unknown how HIV-1 infection raises oncogenic virus-mediated cancer risks in the HIV-1 and oncogenic virus co-infected patients, and thus elucidation of the molecular mechanisms for how HIV-1 expedites the oncogenic viruses-triggered tumorigenesis in the co-infected hosts is imperative for developing therapeutics to cure or impede the carcinogenesis. Hence, this review is focused on HIV-1 and oncogenic virus co-infection-mediated molecular processes in the acceleration of non-AIDS-defining cancers.
dc.description.sponsorshipThe research and APC were support funded by departmental resources to I.-W.P. and K.B., J.P. was supported in part by an F31 DA053151 fellowship from the National Institute on Drug Abuse. M.G. was supported by NIDA award R25DA0043225 to Harlan Jones.
dc.identifier.citationProulx, J., Ghaly, M., Park, I. W., & Borgmann, K. (2022). HIV-1-Mediated Acceleration of Oncovirus-Related Non-AIDS-Defining Cancers. Biomedicines, 10(4), 768. https://doi.org/10.3390/biomedicines10040768
dc.identifier.issn2227-9059
dc.identifier.issue4
dc.identifier.urihttps://hdl.handle.net/20.500.12503/31580
dc.identifier.volume10
dc.publisherMDPI
dc.relation.urihttps://doi.org/10.3390/biomedicines10040768
dc.rights.holderCopyright © 2022 by the authors.
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceBiomedicines
dc.subjectHbv
dc.subjectHcv
dc.subjectHpv
dc.subjecthepatitis
dc.subjecthuman immunodeficiency virus
dc.subjecthuman papillomavirus
dc.titleHIV-1-Mediated Acceleration of Oncovirus-Related Non-AIDS-Defining Cancers
dc.typeArticle
dc.type.materialtext

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