Epidemiologic Assessment of a Targeted Tuberulosis Screening and Treatment Program Based on Geographic and Molecular Clustering

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dc.creatorMoonan, Patrick Kevin
dc.date.accessioned2019-08-22T21:38:32Z
dc.date.available2019-08-22T21:38:32Z
dc.date.issued2005-08-01
dc.date.submitted2013-05-15T14:12:06-07:00
dc.description.abstractMoonan, Patrick K., Epidemiologic Assessment of a Targeted Tuberculosis Screening and Treatment Program Based on Geographic and Molecular Clustering. Doctor of Public Health (Disease Prevention and Control), August 2005, 93 pp., 12 tables, 7 illustrations, bibliography, 148 tables. One of the primary goals of the tuberculosis elimination strategy is to interrupt the transmission of mycobacterium tuberculosis (TB). The most effective way to accomplish this goal is to identify and treat individuals who have active tuberculosis. However, even in highly effected tuberculosis control programs, M. tuberculosis continues to be transmitted to others, largely because most transmission occurs before diagnosis and initiation of therapy. Under the current recommendations, testing should be targeted at specific high-risk populations. While a strategy of targeted testing and treatment of persons most likely to develop tuberculosis is attractive, it is uncertain how best to accomplish this goal. This is the first study to assess the use of geographic and molecular surveillance in guiding a targeted tuberculosis screening and treatment of active tuberculosis and latent tuberculosis infection that monitors potential transmission in a defined high risk geographic area. The results of this geographically targeted program demonstrate significant yield for discovering active cases, latent tuberculosis infection, and recent transmission (TST converters). In this setting, geographically targeted screening identified as many as 19.8 tuberculosis cases per 1,000 persons screened and as many as 292.4 latent tuberculosis infections per 1,000 persons screened. Additionally, successful treatment of these individuals reduced the number of both cases and latent infection identified. Over a three-year period the case detection rate, latent infection detection rate, and TST conversion rate was reduced by 335%, 171% and 285% respectively.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12503/29480
dc.language.isoen
dc.provenance.legacyDownloads0
dc.subjectBacteria
dc.subjectBacterial Infections and Mycoses
dc.subjectClinical Epidemiology
dc.subjectCommunity Health
dc.subjectCommunity Health and Preventive Medicine
dc.subjectDiseases
dc.subjectEpidemiology
dc.subjectGeography
dc.subjectHealth Services Research
dc.subjectImmunology and Infectious Disease
dc.subjectImmunology of Infectious Disease
dc.subjectImmunopathology
dc.subjectInfectious Disease
dc.subjectLife Sciences
dc.subjectMedical Immunology
dc.subjectMedical Sciences
dc.subjectMedical Specialties
dc.subjectMedicine and Health Sciences
dc.subjectOther Geography
dc.subjectPublic Health
dc.subjectmycobacterium tuberculosis
dc.subjecttransmission
dc.subjecthigh risk geographic area
dc.titleEpidemiologic Assessment of a Targeted Tuberulosis Screening and Treatment Program Based on Geographic and Molecular Clustering
dc.typeDissertation
dc.type.materialtext
thesis.degree.departmentSchool of Public Health
thesis.degree.disciplineEpidemiology
thesis.degree.grantorUniversity of North Texas Health Science Center at Fort Worth
thesis.degree.nameDoctor of Public Health

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