A proteomic signature for dementia with Lewy bodies

Simple item page
dc.creatorO'Bryant, Sid E.
dc.creatorFerman, Tanis J.
dc.creatorZhang, Fan
dc.creatorHall, James R.
dc.creatorPedraza, Otto
dc.creatorWszolek, Zbigniew K.
dc.creatorComo, Tori
dc.creatorJulovich, David A.
dc.creatorMattevada, Sravan
dc.creatorJohnson, Leigh A.
dc.creatorEdwards, Melissa
dc.creatorGraff-Radford, Neill R.
dc.creator.orcid0000-0003-0582-5266 (O'Bryant, Sid E.)
dc.creator.orcid0000-0001-7769-8417 (Johnson, Leigh A.)
dc.date.accessioned2022-07-07T13:54:26Z
dc.date.available2022-07-07T13:54:26Z
dc.date.issued2019-03-15
dc.description.abstractIntroduction: We sought to determine if a proteomic profile approach developed to detect Alzheimer's disease would distinguish patients with Lewy body disease from normal controls, and if it would distinguish dementia with Lewy bodies (DLB) from Parkinson's disease (PD). Methods: Stored plasma samples were obtained from 145 patients (DLB n = 57, PD without dementia n = 32, normal controls n = 56) enrolled from patients seen in the Behavioral Neurology or Movement Disorders clinics at the Mayo Clinic, Florida. Proteomic assays were conducted and analyzed as per our previously published protocols. Results: In the first step, the proteomic profile distinguished the DLB-PD group from controls with a diagnostic accuracy of 0.97, sensitivity of 0.91, and specificity of 0.86. In the second step, the proteomic profile distinguished the DLB from PD groups with a diagnostic accuracy of 0.92, sensitivity of 0.94, and specificity of 0.88. Discussion: These data provide evidence of the potential utility of a multitiered blood-based proteomic screening method for detecting DLB and distinguishing DLB from PD.
dc.description.sponsorshipThis grant was supported in part by a grant from the National Alzheimer's Coordinating Center (NACC-2016-04) and grants from the National Institute on Aging (R01AG058537, R01AG054073, R01AG058252, R01AG051848, P50AG016574). Z.K.W. is partially supported by the NIH/NIA (primary) and NIH/NINDS (secondary) 1U01AG045390-01A1, Mayo Clinic Center for Regenerative Medicine, the gift from Carl Edward Bolch, Jr., and Susan Bass Bolch, The Sol Goldman Charitable Trust, and Donald G. and Jodi P. Heeringa.
dc.identifier.citationO'Bryant, S. E., Ferman, T. J., Zhang, F., Hall, J., Pedraza, O., Wszolek, Z. K., Como, T., Julovich, D., Mattevada, S., Johnson, L. A., Edwards, M., Hall, J., & Graff-Radford, N. R. (2019). A proteomic signature for dementia with Lewy bodies. Alzheimer's & dementia (Amsterdam, Netherlands),11, 270-276. https://doi.org/10.1016/j.dadm.2019.01.006
dc.identifier.issn2352-8729
dc.identifier.urihttps://hdl.handle.net/20.500.12503/31537
dc.identifier.volume11
dc.publisherElsevier Inc.
dc.relation.urihttps://doi.org/10.1016/j.dadm.2019.01.006
dc.rights.holderCopyright © 2019 The Authors
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceAlzheimer's & Dementia Diagnosis, Assessment & Disease Monitoring
dc.subjectbiomarker screening
dc.subjectblood biomarkers
dc.subjectdementia with Lewy bodies
dc.subjectdetection
dc.subjectdiagnostic accuracy
dc.subjectParkinson's disease
dc.subject.meshParkinson Disease
dc.subject.meshProteomics
dc.subject.meshLewy Body Disease
dc.titleA proteomic signature for dementia with Lewy bodies
dc.typeArticle
dc.type.materialtext

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
10.1016_j.dadm.2019.01.006.pdf
Size:
339 KB
Format:
Adobe Portable Document Format
Description:
full text article
Download

Collections

Publications -- Sid E. O'Bryant
Publications -- Fan Zhang
Publications -- James R. Hall
Publications -- Leigh A. Johnson