Redox imbalance stress in diabetes mellitus: Role of the polyol pathway

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dc.creatorYan, Liang-Jun
dc.creator.orcid0000-0002-5815-5430 (Liang-Jun Yan)
dc.date.accessioned2022-07-11T18:27:39Z
dc.date.available2022-07-11T18:27:39Z
dc.date.issued2018-04-19
dc.description.abstractIn diabetes mellitus, the polyol pathway is highly active and consumes approximately 30% glucose in the body. This pathway contains 2 reactions catalyzed by aldose reductase (AR) and sorbitol dehydrogenase, respectively. AR reduces glucose to sorbitol at the expense of NADPH, while sorbitol dehydrogenase converts sorbitol to fructose at the expense of NAD(+), leading to NADH production. Consumption of NADPH, accumulation of sorbitol, and generation of fructose and NADH have all been implicated in the pathogenesis of diabetes and its complications. In this review, the roles of this pathway in NADH/NAD(+) redox imbalance stress and oxidative stress in diabetes are highlighted. A potential intervention using nicotinamide riboside to restore redox balance as an approach to fighting diabetes is also discussed.
dc.description.sponsorshipThe writing of this review article was supported in part by UNTHSCseed grants RI10015 and RI10039 and by the National Institutes ofHealth (grant no. R01NS079792).
dc.identifier.citationYan L. J. (2018). Redox imbalance stress in diabetes mellitus: Role of the polyol pathway. Animal models and experimental medicine, 1(1), 7-13. https://doi.org/10.1002/ame2.12001
dc.identifier.issn2576-2095
dc.identifier.issue1
dc.identifier.urihttps://hdl.handle.net/20.500.12503/31568
dc.identifier.volume1
dc.publisherJohn Wiley & Sons Australia, Ltd
dc.relation.urihttps://doi.org/10.1002/ame2.12001
dc.rights.holderCopyright © 2018 The Author.
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceAnimal Models and Experimental Medicine
dc.subjectNadh/nad+
dc.subjectdiabetes mellitus
dc.subjectfructose
dc.subjectoxidative stress
dc.subjectpolyol pathway
dc.subjectredox imbalance stress
dc.titleRedox imbalance stress in diabetes mellitus: Role of the polyol pathway
dc.typeArticle
dc.type.materialtext

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