Application of Structural Retinal Biomarkers to Detect Cognitive Impairment in a Primary Care Setting

Date

2023-02-02

Authors

Mozdbar, Sima
Petersen, Melissa E.
Zhang, Fan
Johnson, Leigh A.
Tolman, Alex
Nyalakonda, Ramyashree
Gutierrez, Alejandra
O'Bryant, Sid E.

ORCID

0000-0001-7769-8417 (Johnson, Leigh A.)
0000-0003-0582-5266 (O'Bryant, Sid)

Journal Title

Journal ISSN

Volume Title

Publisher

IOS Press

Abstract

BACKGROUND: Despite the diagnostic accuracy of advanced neurodiagnostic procedures, the detection of Alzheimer's disease (AD) remains poor in primary care. There is an urgent need for screening tools to aid in the detection of early AD. OBJECTIVE: This study examines the predictive ability of structural retinal biomarkers in detecting cognitive impairment in a primary care setting. METHODS: Participants were recruited from Alzheimer's Disease in Primary Care (ADPC) study. As part of the ADPC Retinal Biomarker Study (ADPC RBS), visual acuity, an ocular history questionnaire, eye pressure, optical coherence tomography (OCT) imaging, and fundus imaging was performed. RESULTS: Data were examined on n = 91 participants. The top biomarkers for predicting cognitive impairment included the inferior quadrant of the outer retinal layers, all four quadrants of the peripapillary retinal nerve fiber layer, and the inferior quadrant of the macular retinal nerve fiber layer. CONCLUSION: The current data provides strong support for continued investigation into structural retinal biomarkers, particularly the retinal nerve fiber layer, as screening tools for AD.

Description

Citation

Mozdbar, S., Petersen, M., Zhang, F., Johnson, L., Tolman, A., Nyalakonda, R., Gutierrez, A., & O'Bryant, S. (2022). Application of Structural Retinal Biomarkers to Detect Cognitive Impairment in a Primary Care Setting. Journal of Alzheimer's disease reports, 6(1), 749-755. https://doi.org/10.3233/ADR-220070

Rights

© 2022 — The authors.

License

Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)