Application of Structural Retinal Biomarkers to Detect Cognitive Impairment in a Primary Care Setting

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dc.creatorMozdbar, Sima
dc.creatorPetersen, Melissa E.
dc.creatorZhang, Fan
dc.creatorJohnson, Leigh A.
dc.creatorTolman, Alex
dc.creatorNyalakonda, Ramyashree
dc.creatorGutierrez, Alejandra
dc.creatorO'Bryant, Sid E.
dc.creator.orcid0000-0001-7769-8417 (Johnson, Leigh A.)
dc.creator.orcid0000-0003-0582-5266 (O'Bryant, Sid)
dc.date.accessioned2023-02-16T14:25:38Z
dc.date.available2023-02-16T14:25:38Z
dc.date.issued2023-02-02
dc.description.abstractBACKGROUND: Despite the diagnostic accuracy of advanced neurodiagnostic procedures, the detection of Alzheimer's disease (AD) remains poor in primary care. There is an urgent need for screening tools to aid in the detection of early AD. OBJECTIVE: This study examines the predictive ability of structural retinal biomarkers in detecting cognitive impairment in a primary care setting. METHODS: Participants were recruited from Alzheimer's Disease in Primary Care (ADPC) study. As part of the ADPC Retinal Biomarker Study (ADPC RBS), visual acuity, an ocular history questionnaire, eye pressure, optical coherence tomography (OCT) imaging, and fundus imaging was performed. RESULTS: Data were examined on n = 91 participants. The top biomarkers for predicting cognitive impairment included the inferior quadrant of the outer retinal layers, all four quadrants of the peripapillary retinal nerve fiber layer, and the inferior quadrant of the macular retinal nerve fiber layer. CONCLUSION: The current data provides strong support for continued investigation into structural retinal biomarkers, particularly the retinal nerve fiber layer, as screening tools for AD.
dc.description.sponsorshipResearch reported in this publication was supported by the National Institute of Aging (NIA) of the National Institutes of Health under Award Number R01AG058537. This study was also funded by the NIA under Award Number U24AG065204, through the Clinician-Scientists Transdisciplinary Aging Research (Clin-STAR) pilot grant, as well as funding from intramural seed grants from the University of North Texas Health Science Center Department of Pharmacology & Neuroscience. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
dc.identifier.citationMozdbar, S., Petersen, M., Zhang, F., Johnson, L., Tolman, A., Nyalakonda, R., Gutierrez, A., & O'Bryant, S. (2022). Application of Structural Retinal Biomarkers to Detect Cognitive Impairment in a Primary Care Setting. Journal of Alzheimer's disease reports, 6(1), 749-755. https://doi.org/10.3233/ADR-220070
dc.identifier.issn2542-4823
dc.identifier.issue1
dc.identifier.urihttps://hdl.handle.net/20.500.12503/32018
dc.identifier.volume6
dc.publisherIOS Press
dc.relation.urihttps://doi.org/10.3233/ADR-220070
dc.rights.holder© 2022 — The authors.
dc.rights.licenseAttribution-NonCommercial 4.0 International (CC BY-NC 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.sourceJournal of Alzheimer's Disease Reports
dc.subjectAlzheimer's disease
dc.subjectcognitive impairment
dc.subjectoptical coherence tomography
dc.subjectretinal biomarkers
dc.titleApplication of Structural Retinal Biomarkers to Detect Cognitive Impairment in a Primary Care Setting
dc.typeArticle
dc.type.materialtext

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