Role of Virally-Encoded Deubiquitinating Enzymes in Regulation of the Virus Life Cycle

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dc.creatorProulx, Jessica
dc.creatorBorgmann, Kathleen
dc.creatorPark, InWoo
dc.creator.orcid0000-0003-0897-390X (Borgmann, Kathleen)
dc.creator.orcid0000-0002-5452-0461 (Proulx, Jessica)
dc.date.accessioned2022-07-12T16:34:46Z
dc.date.available2022-07-12T16:34:46Z
dc.date.issued2021-04-23
dc.description.abstractThe ubiquitin (Ub) proteasome system (UPS) plays a pivotal role in regulation of numerous cellular processes, including innate and adaptive immune responses that are essential for restriction of the virus life cycle in the infected cells. Deubiquitination by the deubiquitinating enzyme, deubiquitinase (DUB), is a reversible molecular process to remove Ub or Ub chains from the target proteins. Deubiquitination is an integral strategy within the UPS in regulating survival and proliferation of the infecting virus and the virus-invaded cells. Many viruses in the infected cells are reported to encode viral DUB, and these vial DUBs actively disrupt cellular Ub-dependent processes to suppress host antiviral immune response, enhancing virus replication and thus proliferation. This review surveys the types of DUBs encoded by different viruses and their molecular processes for how the infecting viruses take advantage of the DUB system to evade the host immune response and expedite their replication.
dc.description.sponsorshipThis work was supported by the Department of Microbiology, Immunology, and Genetics, University of North Texas Health Science Center & T32 AG020494-16 A1 Neurobiology of Aging Fellowship.
dc.identifier.citationProulx, J., Borgmann, K., & Park, I. W. (2021). Role of Virally-Encoded Deubiquitinating Enzymes in Regulation of the Virus Life Cycle. International journal of molecular sciences, 22(9), 4438. https://doi.org/10.3390/ijms22094438
dc.identifier.issn1422-0067
dc.identifier.issue9
dc.identifier.urihttps://hdl.handle.net/20.500.12503/31583
dc.identifier.volume22
dc.publisherMDPI
dc.relation.urihttps://doi.org/10.3390/ijms22094438
dc.rights.holderCopyright © 2021 by the authors.
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceInternational Journal of Molecular Sciences
dc.subjectdeubiquitinases (DUBs)
dc.subjectubiquitin proteasome system
dc.subjectviruses
dc.subject.meshAnimals
dc.subject.meshDeubiquitinating Enzymes / chemistry
dc.subject.meshDeubiquitinating Enzymes / metabolism
dc.subject.meshHost-Pathogen Interactions / immunology
dc.subject.meshHumans
dc.subject.meshImmune Evasion
dc.subject.meshImmunity, Innate / immunology
dc.subject.meshLife Cycle Stages
dc.subject.meshUbiquitin / metabolism
dc.subject.meshUbiquitination
dc.subject.meshViral Proteins / chemistry
dc.subject.meshViral Proteins / metabolism
dc.subject.meshVirus Diseases / enzymology
dc.subject.meshVirus Diseases / immunology
dc.subject.meshVirus Diseases / virology
dc.subject.meshVirus Replication
dc.subject.meshViruses / enzymology
dc.subject.meshViruses / immunology
dc.titleRole of Virally-Encoded Deubiquitinating Enzymes in Regulation of the Virus Life Cycle
dc.typeArticle
dc.type.materialtext

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